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This study investigated the presence and human hazards associated with pesticides and other anthropogenic chemicals identified in kale grown in urban and rural environments. Pesticides and related compounds (i.e., surfactants and metabolites) in kale samples were evaluated using ...

The US EPA has developed a set of annual North American anthropogenic and fire emissions data for criteria air pollutants across 18 broad source catagories for 2002 through 2017.  The sixteen new annual emissions inventories were developed using consistent input data and met...

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When “The Principles of Humane Experimental Technique” was published in 1959, authors William Russell and Rex Burch had a modest goal: to make researchers think about what they were doing in the laboratory—and to do it more humanely. Sixty years later, their gro...

Brain health is a major individual and community issue with impacts on quality of life for the individual and economic wellbeing of the nation. The need to assess and protect the nervous system demands enhancement of biomarker development and the application of precision medicine...

The U.S. Harmful Algal Bloom and Hypoxia Research Control Act calls for robust approaches to forecasting cyanobacterial harmful algal blooms (cyanoHABs). Accurate forecasting technology could save local communities healthcare costs through the early detection of cyanoHABs and the...

Background and Purpose: Per- and polyfluoroalkyl substances (PFAS) are widely used in non-stick coatings, firefighting foams and other products. Their fluorinated state contributes to their unique uses and stability, but also may result in long half-lives in the environment and h...

Per- and polyfluoroalkyl substances (PFAS) are widely used, and their fluorinated state contributes to unique uses and stability but also long half-lives in the environment and humans. PFAS have been shown to be toxic, leading to immunosuppression, cancer, and other adverse healt...

Thyroid hormones (TH) are important to numerous bodily functions such as development and homeostasis and can be useful bellwethers for identifying biologically disruptive compounds. Research into the effects of environmental pollutants such as pesticides and other endocrine disru...

Background/Purpose The US EPA has developed a tiered testing strategy, including high-throughput transcriptomics (HTTr) testing, to identify molecular targets of thousands of environmental chemicals. These findings can be linked to adverse outcomes and can be used in Integrated A...

Seagrass beds provide key benefits, including playing a critical role in climate mitigation. We tested the effects of different eelgrass densities on greenhouse gas (GHG) fluxes at the water-atmosphere interface by creating six treatments (4 reps ea) with different shoot densitie...

Background and Purpose: T cell receptor (TCR)-dependent activation of T cells dictates immune specificity and establishes immunological memory, key features of adaptive immunity. Canonical activation of T cells occurs through engagement of TCRs by interaction with the major histo...

Assaying for thyroid interference is of increasing importance in standardized developmental and reproductive toxicity studies. While serum T4 quantification is an endpoint assessed in developing rats, it is unclear how this measure may correlate to adverse neurodevelopmental outc...

To identify U.S. lead exposure risk hotspots, we expanded upon geospatial statistical methods from a published Michigan case study. Evaluation of identified hotspots using six lead indices, based on housing age and sociodemographic data, showed moderate-to-substantial agreement w...

The declining trend in vehicle emissions has underscored the growing significance of Volatile Organic Compound (VOC) emissions from Volatile Chemical Products (VCP). However, accurately representing VOC chemistry in simplified chemical mechanisms remains challenging due to its ch...

As the world's reservoirs experience drawdowns from reduced precipitation and increased water demand, expanses of sediment are being exposed and colonized by both native and non-native vegetation. Within Lake Powell, the second largest reservoir in the U.S., drought in the Colora...

Global shifts in climatic conditions and anthropogenic disturbances are dramatically modifying the Earth’s ecosystem. Ensuring water security, availability, and quality within this context largely depends on how accurately we can map Global Surface Water Extents (GWSE). Map...

Background and Purpose Biosolids are treated sewage sludge produced as a byproduct of the wastewater treatment process, often applied to land or disposed of in landfills. Under the Clean Water Act, the US EPA Office of Water (OW) has the responsibility to protect human health and...

Background: The Toxic Substances Control Act (TSCA) requires the US Environmental Protection Agency (EPA) to evaluate the hazard and exposure to new and existing chemicals. New chemical notifications are typically data poor and EPA?s Office of Pollution Prevention and Toxics (OPP...

Animal toxicity testing is time and resource intensive, making it difficult to keep pace with the number of substances requiring assessment. Machine learning (ML) models that use chemical structure information and high-throughput experimental data can be helpful in predicting pot...

Numerous qPCR-based methods are available to estimate the concentration of fecal pollution sources in surface waters. However, qPCR fecal source identification data sets often include a high proportion of non-detections (reactions failing to attain a prespecified minimal signal i...

Development of effective pollution mitigation strategies require an understanding of the pollution sources and factors influencing fecal pollution loading. Fecal contamination of Turkey Creek in Gulfport, Mississippi, one of the nation's most endangered creeks, was studied throug...

South Florida is a subtropical environment with diverse ecological and human communities that rely on a complex water system undergoing the costliest restoration in U.S. history. Pesticide and metal input to the aquatic systems of South Florida can impact the capabilities of main...

Read-across is a well-established data-gap filling technique used within analogue or category approaches. Acceptance remains an issue, mainly due to the difficulties of addressing residual uncertainties associated with a read-across prediction and because assessments are expert-d...

Read-across is a data-gap filling technique utilised to predict the toxicity of a target chemical using data from similar source analogues. Read-across acceptance remains an issue, mainly due to the difficulties of addressing residual uncertainties and because read-across is stil...