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This presentation will define and present background information on uptake factors and their utility in multi-route exposure assessment, including how they can be derived using a PBPK model, factors that may impact their derivation and implications for exposure assessment and ris...

Uptake factors are used in conjunction with epidemiologic studies as a way to refine exposure estimates to include chemical absorption during multiple water use activities.&nbsp; For THMs, a class of volatile disinfection byproducts that are readily absorbed via dermal and inhala...

Uptake factors are used in conjunction with epidemiologic studies to refine exposure estimates to include chemical absorption during multiple water use activities (e.g., Savitz et al., 2006; Iszatt et al., 2011).&nbsp; For THMs, a class of volatile disinfection byproducts that ar...

&nbsp; &nbsp; &nbsp;Diversity Outbred (DO) mice that mimic human heterozygosity and are highly genetically diverse (Alison Harrill, US EPA) &nbsp; &nbsp; &nbsp;Diversity Outbred (DO) mice that mimic human heterozygosity and are highly genetically diverse provide an ideal resource...

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Few studies are available on the environmental and toxicological effects of perfluoroalkyl ether carboxylic acids (PFECAs), such as GenX, which are replacing legacy PFAS in manufacturing processes. To collect initial data on the toxicity and toxicokinetics of a longer-chain PFECA...

Due to the pervasive detection of multiple PFAS in human and environmental matrices, many health-based agencies are employing or pursuing cumulative assessment and regulatory approaches.&nbsp; However, the literature is lacking mammalian in vivo studies that test additivity by co...

There is increasing interest in the application of dose-response modeling approaches to broad/non-targeted profiling data, such as transcriptomics, in order to derive mechanism-agnostic reference values for potentially hazardous chemicals. In this session, I will present an overv...

In toxicology, dose-response analysis seeks the calculation of a benchmark dose (BMD) and benchmark dose lower (BMDL) bound as a point-of-departure (POD) where statistically significant exposure-related change would be observed. While dose-response analysis of single or multivari...

This is a training presentation to the EPA Tools and Resources Webinar. The ChemExpo Knowledgebase is a new ORD tool for disseminating information on how chemicals are used in commerce, including in consumer products.

Targeted methods have long been the gold standard in chemical monitoring for exposure assessment. However, with the increased need to identify emerging contaminants, monitoring studies have shifted towards approaches like non-targeted analysis (NTA) utilizing high-resolution mass...

To reduce reliance on long-term in vivo studies, short-term data linking early molecular-based measurement to later adverse health effects is needed.&nbsp; Although transcriptional-based benchmark dose (BMDT) modeling has been used to estimate potencies and stratify chemicals bas...

Although airborne fluorotelomer alcohols (FTOHs) have been characterized in occupational settings, the residential indoor air burden of FTOHs from consumer products, building materials, and household dust is not well understood. Data for key parameters controlling emissions of FT...

Pharmacokinetics/Toxicokinetics enables quantitative characterization of chemical risk by allowing insight into the dose-response relationship. However, some aspects of kinetics are chemical-specific and require parameters and other features that must be derived from data and/or ...

Recent reports indicate an increase in the projection of storms as a result of climate change (https://www.gfdl.noaa.gov/global-warming-and-hurricanes/). The 2022 hurricane season started May 15, in the Eastern Pacific Ocean, and June 1 in the Atlantic Ocean. In September 2022, t...

Onsite non-potable water systems (ONWS) collect and treat local source waters for non-potable end uses such as toilet flushing and irrigation. Quantitative microbial risk assessment (QMRA) has been used to set pathogen log10-reduction targets (LRTs) for ONWS to achieve the risk b...

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Polychlorinated biphenyls (PCBs) are a group of chemicals that occur in the environment as mixtures of individual congeners. Despite a large volume of literature documenting adverse health effects from exposure to these mixtures, the relative sensitivity of various health outcome...

Benchmark dose modeling of gene response from short-term chemical exposures can identify points of departure consistent with chronic adverse effects. Widespread use of this approach could enhance the efficiency of human and ecological risk assessments. Moreover, an understanding ...

EPA’s draft document describes the planning and problem formulation steps of cumulative risk assessments (CRAs) and offers guidelines for when such assessments might be appropriate. The document provides recommendations to aid in developing a CRA analysis plan, but they do not pr...

Stress plus chemical exposure may produce effects not observed with chemical exposure alone. Therefore, there is a need for new approach methods that can rapidly screen chemicals for their interaction with stressed biological systems, which will advance understanding of inter- an...

In this workshop, real world examples from publicly available, peer reviewed, completed risk assessments will be used as teaching aids.&nbsp; Course modules will be organized according to the key components of the risk analysis process: hazard characterization, dose response anal...

In October 2023, the IRIS Program released the draft IRIS Toxicological Review of Inorganic Arsenic for public comment and external peer review. The IRIS assessment of inorganic arsenic will undergo an independent external scientific peer review managed by EPA’s Science Advisory ...

To establish toxicity reference values, risk assessments require reliable&nbsp;methods with well-characterized uncertainty. Next generation risk assessment&nbsp;will require in vitro to in vivo extrapolation (IVIVE) to translate observed cellular&nbsp;responses to whole organisms...

Multiple States have explored the implementation of in vitro new approach methodologies (NAMs) as component of water quality monitoring programs to detect biological activity indicative of potential contaminant and/or contaminant mixture occurrence. Polycyclic aromatic compounds ...