Science Inventory

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Per- and polyfluoroalkyl substances (PFAS) are a group of man-made chemicals that have been in use since the 1940s in a wide array of consumer products. PFAS are persistent in the environment and bioaccumulate. Thermal treatment methods are currently applied to a variety of mater...

The Equitable Resilience Builder (ERB) is a newly released tool to support community resilience planning. ERB is a downloadable application that supports communities in strengthening resilience to disasters and climate change. It walks a core team of users through a guided proces...

Presentation presented to the 1st International Electronic Conference on Toxics (IECTO)Session E. Novel Methods in Toxicology Research

Toxicological outcomes in vivo result from complex interactions among molecular, cellular and tissue-level damage responses which are difficult to recapitulate in vitro or extrapolate from data-based Machine Learning or molecular-level computer simulations. Mechani...

This is a lecture to the Colorado Produced Water Consortium to review methods that are used by EPA to evaluate chemicals and mixtures.

Hepatic steatosis (fatty liver disease) is a pathological condition that may alter xenobiotic metabolism, thereby increasing susceptibility to environmental toxicants. Here we used a metabolically competent human liver-derived cell line – HepaRG – to model steatosis f...

This sub-product provides an overview on our work with novel technologies to separate and destroy PFAS in residual waste streams (e.g., incinerator scrubber water, reverse osmosis retentate). This presentation focuses on a stepwise process where adsorbents first separate PFAS and...

The purpose of this work is to provide data and information to refine existing guidance about how to flush per- and polyfluoroalkyl substances (PFAS) from firefighting systems, specifically hangar systems and Aircraft Rescue and Firefighting (ARFF) vehicles. It is relevant to the...

Radioactive fallout could have debilitating effects on drinking water and wastewater systems. At least some drinking water system operators have plans to mitigate the effects of a contaminated water source, but most, if not all, wastewater operators have no such plans.  Both...

Legionella pneumophila (Lp) is an opportunistic drinking water pathogen that can cause infections through the inhalation of Lp-containing aerosols. Lp can occur in premise plumbing systems as these systems often have low disinfection residual, high surface area-to-volume ratios, ...

The threat of cascading and compounding disasters in low-income and underrepresented communities with hazardous and polluting sites makes urgent the need to build resilience. The Equitable Resilience Builder (ERB) is a new tool designed for situations where capacity and resources...

This presentation covers updates as of March 2024 regarding EPA methods for per- and polyfluoroalkyl substances (PFAS) as well as ongoing method development work within EPA Office of Research and Development (ORD). EPA Methods 1633 and 1621 were finalized on January 31, 2024. Fut...

These are slides to give an overview of applied NAMs for hazard, using the example workflow of performing an endocrine assessment using ToxCast data and models, followed by calculation of a bioactivity:exposure ratio. Then, examples of applied bioactivity:exposure ratios or point...

Phagocytosis is essential for proper innate immune defense across many organisms. When exposed to immunosuppressive environmental chemicals, phagocytosis may be inhibited, potentially increasing susceptibility to pathogens. To quantify the immunosuppressive potential of a chemica...

Presentation to the European Regulation & Innovation Forum (ERIF) Science Taskforce Meeting April 2024. The US Environmental Protection Agency works with program offices internally, other US federal Agencies, international partners, and diverse stakeholder groups to develop m...

While SWMM has arguably played a pivotal role in pollution control in collection systems since its introduction, traditional applications using the model have been relatively static. They typically involve calibrating and validating SWMM models with data collected and curated for...

This sub-product is an invited virtual presentation to a meeting with Maldives governmental and non-governmental stakeholders hosted by the World Bank. The presentation describes experiences applying decision analysis tools in a deliberative setting with the city of Dania Beach.&...

Collocation of air quality sensors at existing regulatory air monitoring sites allows sensor data comparison against quality-assured reference data and is a cost-effective method for understanding the performance of lower-cost air sensors. In some cases, collocations can allow fo...

Stable isotope ratios integrate, indicate, record, and trace fundamental processes in hydrology and ecology.  Stored within the atoms of samples, stable isotope ratios of specific elements unlock stories about ecological processes that impact water quality and quantity.&nbsp...

Structural models based on Bayesian networks are powerful knowledge representation tools that can capture diverse problem analysis structures and provide a basis for quantitative analysis and weight of evidence. They have only recently been developed and applied in fields ranging...

This invited keynote presentation provides compressive definitions regarding sustainable development, sustainability assessment and design, life cycle analysis, and their application in manufacturing more environmentally friendly chemicals with less occupational exposure. Similar...

Background and PurposeSoil and dust are effective sorbents for many organic chemicals and are known to concentrate lipophilic, less volatile, environmental pollutants. For children’s risk assessment, this is important, primarily because children consume relatively large qua...

SOT 2024 Abstract Background and Purpose: The use of in vitro systems to model the effects of inhalation exposures has focused on using differentiated primary human bronchial epithelial cell (dpHBEC) cultures as they recapitulate key features of the airway epithelium in vivo.&nbs...

Manufacturing advancements in three-dimensional (3D) printing of plastic polymers have outpaced our understanding of exposure risks for domestic use. One understudied aspect is the release of metal additives incorporated into plastic polymers before and after printing. Metal addi...

This is a power point presentation that summarizes the potential for phototoxicity of crude and refined oils. The presentation will cover the phototoxic components of oil, mechanisms of petroleum phototoxicity, and the environmental and biological modulation of phototoxicity.