Science Inventory

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Harrill, J., L. Everett, D. Haggard, J. Bundy, C. Willis, I. Shah, K. Friedman, D. Basili, A. Middleton, AND R. Judson. Exploring the Effects of Experimental Parameters and Data Modeling Approaches on In Vitro Transcriptomic Point-of-Departure Estimates. TOXICOLOGY. Elsevier Science Ltd, New York, NY, 501:153694, (2024). https://doi.org/10.1016/j.tox.2023.153694

Haselman, Jonathan, J. Nichols, K. Mattingly, M. Hornung, AND S. Degitz. A biologically based computational model for the hypothalamic-pituitary-thyroid (HPT) axis in Xenopus laevis larvae. MATHEMATICAL BIOSCIENCES. Elsevier Science Ltd, New York, NY, 362:109021, (2023). https://doi.org/10.1016/j.mbs.2023.109021

Eccles, K., A. Karmaus, N. Kleinstreuer, F. Parham, C. Rider, J. Wambaugh, AND K. Messier. A geospatial modeling approach to quantifying the risk of exposure to environmental chemical mixtures via a common molecular target. SCIENCE OF THE TOTAL ENVIRONMENT. Elsevier BV, AMSTERDAM, Netherlands, 855:158905, (2022). https://doi.org/10.1016/j.scitotenv.2022.158905

Shankar, P. AND D. Villeneuve. AOP Report: Aryl Hydrocarbon Receptor Activation Leads to Early–Life Stage Mortality via Sox9 Repression-Induced Craniofacial and Cardiac Malformations. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 42(10):2063-2077, (2023). https://doi.org/10.1002/etc.5699

Nyffeler, J., C. Willis, F. Harris, M. Foster, B. Chambers, M. Culbreth, R. Brockway, S. Davidson-Fritz, D. Dawson, I. Shah, K. Paul-Friedman, D. Chang, L. Everett, J. Wambaugh, G. Patlewicz, AND J. Harrill. Application of Cell Painting for chemical hazard evaluation in support of screening-level chemical assessments. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, 468:116513, (2023). https://doi.org/10.1016/j.taap.2023.116513

Eytcheson, S., J. Olker, K. Friedman, M. Hornung, AND S. Degitz. Assessing utility of thyroid in vitro screening assays through comparisons to observed impacts in vivo. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 144:105491, (2023). https://doi.org/10.1016/j.yrtph.2023.105491

Schaupp, C., E. Maloney, K. Mattingly, J. Olker, AND D. Villeneuve. Comparison of in silico, in vitro, and in vivo toxicity benchmarks suggests a role for ToxCast data in ecological hazard assessment. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 195(2):145-154, (2023). https://doi.org/10.1093/toxsci/kfad072

Schaupp, C., E. Maloney, K. Mattingly, J. Olker, AND D. Villeneuve. Comparison of in silico, in vitro, and in vivo toxicity benchmarks suggests a role for ToxCast data in ecological hazard assessment. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 195(2):145-154, (2023). https://doi.org/10.1093/toxsci/kfad072

Carstens, K., T. Freudenrich, K. Wallace, S. Choo, A. Carpenter, M. Smeltz, M. Clifton, Matthew Henderson, A. Richard, G. Patlewicz, B. Wetmore, K. Friedman, AND T. Shafer. Evaluation of Per- and Polyfluoroalkyl Substances (PFAS) In Vitro Toxicity Testing for Developmental Neurotoxicity. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 36(3):402-419, (2023). https://doi.org/10.1021/acs.chemrestox.2c00344

Garnovskaya, M., M. Feshuk, W. Stewart, K. Friedman, R. Thomas, AND C. Deisenroth. Evaluation of a High-throughput H295R Homogenous Time Resolved Fluorescence Assay for Androgen and Estrogen Steroidogenesis Screening. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 92:105659, (2023). https://doi.org/10.1016/j.tiv.2023.105659

Baker, N., J. Pierro, L. Taylor, AND T. Knudsen. Identifying candidate reference chemicals for in vitro testing of the retinoid pathway for predictive developmental toxicity. ALTEX. Society ALTEX Edition, Kuesnacht, Switzerland, 40(2):217-236, (2023). https://doi.org/10.14573/altex.2202231

Boyce, M., K. Favela, J. Bonzo, A. Chao, L. Lizarraga, L. Moody, E. Owens, G. Patlewicz, I. Shah, J. Sobus, R. Thomas, A. Williams, A. Yau, AND J. Wambaugh. Identifying xenobiotic metabolites with in silico prediction tools and LCMS suspect screening analysis. Frontiers in Toxicology. Frontiers, Lausanne, Switzerland, 5:1051483, (2023). https://doi.org/10.3389/ftox.2023.1051483

Loken, L., S. Corsi, D. Alvarez, G. Ankley, A. Baldwin, B. Blackwell, L. DeCicco, M. Nott, S. Oliver, AND D. Villeneuve. Prioritizing Pesticides of Potential Concern and Identifying Potential Mixture Effects in Great Lakes Tributaries Using Passive Samplers. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 42(2):340-366, (2023). https://doi.org/10.1002/etc.5491

Feshuk, M., L. Kolaczkowski, K. Dunham, S. Davidson-Fritz, K. Carstens, J. Brown, R. Judson, AND K. Friedman. The ToxCast Pipeline: Updates to Curve-fitting Approaches and Database Structure. Frontiers in Toxicology. Frontiers, Lausanne, Switzerland, 5:1275980, (2023). https://doi.org/10.3389/ftox.2023.1275980

Korunes, K., J. Liu, R. Huang, M. Xia, K. Houck, AND C. Corton. A gene expression biomarker for predictive toxicology to identify chemical modulators of NF-κB. PLOS ONE . Public Library of Science, San Francisco, CA, 17(2):e0261854, (2022). https://doi.org/10.1371/journal.pone.0261854

Haselman, Jonathan, J. Olker, P. Kosian, J. Korte, J. Denny, J. Tietge, M. Hornung, AND S. Degitz. Characterization of the Mechanistic Linkages Between Iodothyronine Deiodinase Inhibition and Impaired Thyroid-Mediated Growth and Development in Xenopus Laevis Using Iopanoic Acid. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 187(1):139-149, (2022). https://doi.org/10.1093/toxsci/kfac014

Hopperstad, K., D. DeGroot, T. Zurlinden, C. Brinkman, R. Thomas, AND C. Deisenroth. Chemical Screening in an Estrogen Receptor Transactivation Assay with Metabolic Competence. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 187(1):112-126, (2022). https://doi.org/10.1093/toxsci/kfac019

Boyce, M., B. Meyer, C. Grulke, L. Lizarraga, AND G. Patlewicz. Comparing the performance and coverage of selected in silico (liver) metabolism tools relative to reported studies in the literature to inform analogue selection in read-across: A case study. Computational Toxicology. Elsevier B.V., Amsterdam, Netherlands, 21:100208, (2022). https://doi.org/10.1016/j.comtox.2021.100208

Kuo, B., M. Beal, J. Wills, P. White, F. Marchetti, A. Nong, T. Barton-Maclaren, K. Houck, AND C. Yauk. Comprehensive interpretation of in vitro micronucleus test results for 292 chemicals: from hazard identification to risk assessment application. Archives of Toxicology. Springer, New York, NY, 96(7):2067-2085, (2022). https://doi.org/10.1007/s00204-022-03286-2

Pierro, J., B. Ahir, Nancy C. Baker, N. Kleinsteuer, M. Xia, AND T. Knudsen. Computational model for fetal skeletal defects potentially linked to disruption of retinoic acid signaling. Frontiers in Pharmacology. Frontiers, Lausanne, Switzerland, 13:971296, (2022). https://doi.org/10.3389/fphar.2022.971296

Olker, J., J. Korte, Jonathan Haselman, M. Hornung, AND S. Degitz. Cross-species comparison of chemical inhibition of human and Xenopus iodotyrosine deiodinase. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 249:106227, (2022). https://doi.org/10.1016/j.aquatox.2022.106227

Nicolas, C., M. Linakis, M. Minto, K. Mansouri, R. Clewell, M. Yoon, J. Wambaugh, G. Patlewicz, P. McMullen, M. Andersen, AND H. Clewell. Estimating provisional margins of exposure for data-poor chemicals using high-throughput computational methods. Frontiers in Pharmacology. Frontiers, Lausanne, Switzerland, 13:980747, (2022). https://doi.org/10.3389/fphar.2022.980747

Wambaugh, J. AND J. Rager. Exposure forecasting – ExpoCast – for data-poor chemicals in commerce and the environment. Journal of Exposure Science and Environmental Epidemiology . Nature Publishing Group, London, Uk, 32:783-793, (2022). https://doi.org/10.1038/s41370-022-00492-z

Hubbard, L., D. Kolpin, C. Givens, B. Blackwell, P. Bradley, J. Gray, R. Lane, J. Masoner, R. McCleskey, K. Romanok, M. Sandstrom, K. Smalling, AND D. Villeneuve. Food, Beverage, and Feedstock Processing Facility Wastewater: a Unique and Underappreciated Source of Contaminants to U.S. Streams. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 56(2):1028-1040, (2022). https://doi.org/10.1021/acs.est.1c06821

Beal, M., M. Gagne, S. Kulkarni, G. Patlewicz, R. Thomas, AND T. Barton-Maclaren. Implementing in vitro Bioactivity Data to Modernize Priority Setting of Chemical Inventories. ALTEX. Society ALTEX Edition, Kuesnacht, Switzerland, 39(1):123-139, (2022). https://doi.org/10.14573/altex.2106171