Main Title |
5-Methylhexanoic Acid Developmental Toxicity Testing. |
Author |
Narotsky., M. G. ;
|
CORP Author |
ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
Jan 91 |
Year Published |
1991 |
Report Number |
EPA-68-02-4450; EPA/600/1-91/001; |
Stock Number |
PB91-141838 |
Additional Subjects |
Toxicity ;
Aliphatic acids ;
Valproate ;
Teratogens ;
Rats ;
Dose-response relationships ;
Females ;
Body weight ;
Tables(Data) ;
Reproduction(Biology) ;
Litter size ;
Structure-activity relationship ;
Parturition ;
5-Methylhexanoic acid
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB91-141838 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
23p |
Abstract |
As part of an investigation of the developmental effects and structure-activity relationships of aliphatic acids, 5-methylhexanoic acid was administered by gavage to Sprague-Dawley rats on gestation days 6-15 at doses of 0, 300, and 400 mg/kg/day. The dams were allowed to deliver and their litters were examined through postnatal day 6. Pups that were found dead were examined for soft-tissue alterations. On day 6, two survivors per litter were preserved for skeletal examination. Maternal toxicity was demonstrated at both 300 and 400 mg/kg by reduced weight gains, altered respiration (rales, dyspnea) and death. Body weight losses early in the treatment period were also evident at 400 mg/kg. In spite of the marked maternal toxicity present, there were no clear developmental effects; litter size, pre- and postnatal viability, and pup weights were unaffected by treatment. Skeletal examinations of selected pups also revealed no compound effects. |
Supplementary Notes |
Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
Category Codes |
57Y; 57Q |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
107432797 |
Origin |
NTIS |
Type |
CAT |