Main Title |
Effect of Flavanone on Mixed-Function Oxidase and Conjugation Reactions in Rats (Journal Version). |
Author |
Trela, B. A. ;
Carlson, G. P. ;
|
CORP Author |
Purdue Univ., Lafayette, IN.;Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1987 |
Year Published |
1987 |
Report Number |
EPA/600/J-87/408; |
Stock Number |
PB89-105548 |
Additional Subjects |
Xenobiotics ;
Enzyme induction ;
Mixed function oxidases ;
Glutathime trasferases ;
Glucuronyltransferase ;
Liver ;
Laboratory animals ;
Oxygen heterocyclic compounds ;
Toxicity ;
Reprints ;
Flavanone
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB89-105548 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
7p |
Abstract |
Flavanone administered to female Fischer 344 rats at doses up to 1.00 mmol/kg/day for seven days did not induce ethylmorphine demethylation, aniline hydroxylation, hexobarbital oxidation or aldrin epoxidation. Flavanone administered at a dose of 0.05 mmol/kg/day for seven days increased glutathione-S-transferase activity with 1,2-dichloro-4-nitrobenzene and 1,2-epoxy-3-(p-nitrophenoxy)propane as substrates, and increased the glucuronidation of 1-naphthol and at 0.20 mmol/kg the glucuronidation of chloramphenicol. Flavanone administration did not alter sulfotransferase activity with 2-naphthol as the substrate, or enhance glutathione-S-transferase or glucuronyltransferase activity when added in vitro. |
Supplementary Notes |
Pub. in Xenobiotica, v17 n1 p11-16 1987. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Effect of Flavanone on Mixed-Function Oxidase and Conjugation Reactions in Rats (Journal Version). |
Category Codes |
57B; 57Y |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
833027478 |
Origin |
NTIS |
Type |
CAT |