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OLS Field Name OLS Field Data
Main Title Interaction between methyl mercury and radiation on nervous systems
Author Hupp, Eugene W. ; Day, Dalton ; Hardcastle, James ; Hines, John ; Minnich., James
Other Authors
Author Title of a Work
Hupp, Eugene W.
CORP Author Texas Woman's Univ., Denton.;Health Effects Research Lab., Research Triangle Park, N.C. Experimental Biology Div.
Publisher Environmental Sciences Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency,
Year Published 1977
Report Number EPA-600/1-77-006; EPA-R-800282
Stock Number PB-265 873
Subjects Methylmercuric chloride--Physiological effect ; Radiation--Physiological effect ; Rats--Effect of radiation on ; Hamsters--Effect of radiation on ; Monkeys--Effect of radiation on
Additional Subjects Radiation effects ; Nervous system ; Neurology ; Toxicology ; Laboratory animals ; Experimental data ; Rats ; Hamsters ; Monkeys ; Physiology ; Histology ; Brain ; Behavior ; X rays ; Stress(Physiology) ; Synergistic effects ; Mercury/methyl ; Air pollution effects(Animals) ; Environmental health
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
NTIS  PB-265 873 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation 118 p. : ills. ; 28 cm.
Abstract The interaction between methyl mercury and ionizing radiation was investigated in a series of experiments using rats, hamsters, and squirrel monkeys to study the effects produced and possible mechanisms of action. Parameters evaluated included several measurements of behavior, brain electrical activity, lethality, blood-brain barrier permeability, neurotransmitter and mercury concentration in various brain areas, and brain histology. In some cases the effects of the co-insult were less than or at least no greater than at least one of the two insults applied alone. Possible mechanisms of action include opposite effects of the two insults on the blood-brain barrier, with radiation increasing permeability and methyl mercury decreasing it. Radiation may also elicit a proliferation of peroxisome-like organelles which protect against the effects of methyl mercury.
Notes "EPA-600/1-77-006" "January 1977" "Bibliographical references (p.107-117)
Place Published Research Triangle Park, NC :
Corporate Au Added Ent United States. Environmental Protection Agency. Office of Research and Development. ; Environmental Sciences Research Laboratory.
PUB Date Free Form 1977.
Series Title Traced Ecological health effects research series
NTIS Prices PC A07/MF A01
BIB Level m
Cataloging Source OCLC/T
OCLC Time Stamp 20030611122447
Language eng
Origin NTIS
OCLC Rec Leader 01248nam 2200313Ka 45020