||Induced Cytochrome P4501A in Winter Flounder, 'Pleuronectes americanus', from Offshore and Coastal Sites.
Monosson, E. ;
Stegeman, J. J. ;
||AScI Corp., Narragansett, RI. ;Woods Hole Oceanographic Institution, MA. Dept. of Biology.;Environmental Research Lab., Narragansett, RI.
||EPA-R813155; EPA/600/J-94/504 ; ERLN-X190
Water pollution effects(Animals) ;
Fish diseases ;
Liver diseases ;
Biological effects ;
Marine animals ;
Coastal regions ;
Cape Cod ;
Georges Bank ;
CYP1A(Cytochrome P4501A) ;
Winter flounders ;
Atlantic Coast(United States) ;
Pleuronectes americanus ;
Aroclor 1254 ;
Ah receptor proteins
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||In this study, we measured the content and activity of CYP1A in liver of winter flounder, Pleuronectes americanus, populations over a large geographic region ranging from New York , U.S.A., to New Brunswick, Canada, and investigated the relationship between content and activity of CYP1A and the concentration of PCBs in livers of flounder from sites along the New York and New England coast and Georges Bank. This comparison was the outgrowth of our search for flounder that would show at most slight indication of exposure to Ah receptor agonists or other contaminants. Locations of such 'reference' populations would be useful in helping to establish the etiology of hepatic neoplastic and other diseases of flounder living in the vicinity of contaminated sediments. Flounders in some locales bear neoplastic and other histological diseases that are thought to derive from environmental contamination.
||Pub. in Canadian Jnl. of Fisheries and Aquatic Science, v51 p933-941 1994. Also pub. as Woods Hole Oceanographic Institution, MA. Dept. of Biology rept. no. WHOI-CONTRIB-8148. Prepared in cooperation with Woods Hole Oceanographic Institution, MA. Dept. of Biology. Sponsored by Environmental Research Lab., Narragansett, RI.
|NTIS Title Notes
||Reprint: Induced Cytochrome P4501A in Winter Flounder, 'Pleuronectes americanus', from Offshore and Coastal Sites.
||68D; 47D; 57H; 57Z
||PC A03/MF A01