Main Title |
Enhanced Mortality and Liver Damage in Virus-Infected Mice Exposed to p-Xylene. |
Author |
Selgrade, M. K. ;
Daniels, M. J. ;
Jaskot, R. H. ;
Robinson, B. L. ;
Allis, J. W. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Immunotoxicology Branch. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC. |
Publisher |
c1993 |
Year Published |
1993 |
Report Number |
EPA/600/J-94/047; |
Stock Number |
PB94-137072 |
Additional Subjects |
Xylenes ;
Liver ;
Toxicity ;
Mortality ;
Virus diseases ;
Mice ;
Cytochrome P-450 ;
Cytomegaloviruses ;
Aspartate aminotransferase ;
Alanine aminotransferase ;
Body weight ;
Organ weight ;
Lactate dehydrogenase ;
Isoenzymes ;
Blood chemical analysis ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB94-137072 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
18p |
Abstract |
This study assessed effects of exposure to p-xylene, a ubiquitous air pollutant, on mice infected with murine cytomegalovirus (MCMV), a mouse model for a common human virus. Mice were exposed to filtered air, 600 or 1,200 ppm p-xylene 6 h/d for 4 d and infected with a sublethal dose of MCMV after the first exposure. No deaths occurred among uninfected, p-xylene-exposed mice or infected, air-exposed mice; 34% and 0% mortality occurred respectively in infected mice exposed to 1,200 and 600 ppm p-xylene. Virus titers in the liver and splenic natural killer cell activity were unaffected by exposure to 1,200 ppm p-xylene. MCMV significantly suppressed and p-xylene significantly increased total P-450 levels in the liver, but there was no significant interaction between the two Isozymes 1A1, 2B1/B2, and 2E1 were decreased to a similar degree, suggesting that the virus does not target specific isozymes. Enhanced mortality was not due to immune suppression. While p-xylene potentiated liver damage was caused by the virus, the magnitude of serum enzyme activities indicates that this damage was not a likely cause of death. |
Supplementary Notes |
Pub. in Jnl. of Toxicology and Environmental Health, v40 n1 p129-144 Sep 93. Prepared in cooperation with ManTech Environmental Technology, Inc., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Enhanced Mortality and Liver Damage in Virus-Infected Mice Exposed to p-Xylene. |
Category Codes |
57Y; 57K; 57F |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
407719928 |
Origin |
NTIS |
Type |
CAT |