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OLS Field Name OLS Field Data
Main Title Coronavirus Replication and Reverse Genetics [electronic resource] /
Author Enjuanes, Luis.
Publisher Springer Berlin Heidelberg,
Year Published 2005
Call Number QR355-502
ISBN 9783540267652
Subjects Medicine. ; Medical virology.
Internet Access
Description Access URL
Collation XI, 257 p. 49 illus. online resource.
Notes Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes Coronavirus Genome Structure and Replication -- Coronavirus Transcription: A Perspective -- The Coronavirus Replicase -- Viral and Cellular Proteins Involved in Coronavirus Replication -- Coronavirus Reverse Genetics by Targeted RNA Recombination -- Coronavirus Reverse Genetics and Development of Vectors for Gene Expression -- Reverse Genetics of Coronaviruses Using Vaccinia Virus Vectors -- Development of Mouse Hepatitis Virus and SARS-CoV Infectious cDNA Constructs. Coronaviruses are the RNA viruses with the largest genome known to date (27 to 32 kb). Members of this virus family affect most domestic animal species, causing important socio-economical losses, and also infect humans. Human coronaviruses were known to cause the winter common cold, a mild infection without important pathological consequences except in immuno-compromised patients. Recently, two new human coronaviruses have emerged, one causing the Severe and Acute Respiratory Syndrome (SARS) that infected more than 8000 individuals, leading to more than 800 deaths in 32 countries. This epidemic mobilized the World Health Organization, which launched travel restrictions to certain parts of the world for the first time in the last 50 years. The fact that coronaviruses, as many other viruses, crossed the species barrier to infect humans has posed a serious challenge to scientists involved in animal and human health. Control of coronavirus-induced diseases can only be the consequence of research on virus molecular biology and pathogenesis. This book contains information on virus genome structure, mechanism of replication and transcription, and the development of tools that make possible reverse genetic studies to understand virus-host interactions and the molecular basis of virus pathogenesis. The book also provides essential information for the development of classical and recombinant vaccines to control coronavirus infections.
Place Published Berlin, Heidelberg
Corporate Au Added Ent SpringerLink (Online service)
Title Ser Add Ent Current Topics in Microbiology and Immunology, 287
Host Item Entry Springer eBooks
PUB Date Free Form 2005
Series Title Untraced Current Topics in Microbiology and Immunology, 287
BIB Level m
Medium computer
Content text
Carrier online resource
Cataloging Source OCLC/T
OCLC Time Stamp 20131220132816
Language eng
OCLC Rec Leader 03327nam a22004215i 45