||Use of Respiratory-Cardiovascular Responses of Rainbow Trout ('Salmo gairdneri') in Identifying Acute Toxicity Syndromes in Fish: Part 2. Malathion, Carbaryl, Acrolein and Benzaldehyde.
McKim, J. M. ;
Schmieder, P. K. ;
Niemi, G. J. ;
Carlson, R. W. ;
Henry, T. R. ;
||Environmental Research Lab.-Duluth, MN. ;Minnesota Univ.-Duluth.
Cholinesterase inhibitors ;
Cardiovascular system ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||An in vivo fish model was used to monitor the respiratory-cardiovascular responses of individually spinally transected rainbow trout exposed to acutely toxic aqueous concentrations of two acetylcholinesterase (AChE) inhibitors, malathion and carbaryl, and two mucous membrane irritants, acrolein and benzaldehyde. Individual principal components analyes of the cardiovascular-respiratory responses of fish exposed to the four chemicals showed that the variables were highly correlated and that the first two principal components explained 55 to 70% of the variation in the 18 parameters analyzed. Sets of toxic responses were developed to describe two new fish acute toxicity syndromes (FATS), one for AChE inhibitors and one for respiratory irritants. These were combined with the FATS for respiratory uncouplers and narcotics from previous work prior to discriminant function analysis (DFA). DFA was used to predict the specific FATS for a chemical based on the cardiovascular-respiratory responses observed during intoxication. DFA on these responses resulted in a 100% correct separation of four specific FATS for all 32 trout tested. (Copyright (c) Environmental Toxicology and Chemistry, 1987.)
||Pub. in Environmental Toxicology and Chemistry, v6 p313-328 Apr 87. See also PB88-107065. Prepared in cooperation with Minnesota Univ.-Duluth.
|NTIS Title Notes
||Reprint: Use of Respiratory-Cardiovascular Responses of Rainbow Trout ('Salmo gairdneri') in Identifying Acute Toxicity Syndromes in Fish: Part 2. Malathion, Carbaryl, Acrolein and Benzaldehyde.
|PUB Date Free Form
||57Y; 57H; 57Z; 68G
||PC A03/MF A01