||Influence of Cytochrome P450 Mixed-Function Oxidase Induction on the Acute Toxicity to Rainbow Trout 'Salmo gairdner' of Primary Aromatic Amines.
Hermens, J. L. M. ;
Bradbury, S. P. ;
Broderius, S. J. ;
||Environmental Research Lab.-Duluth, MN. ;Utrecht Rijksuniversiteit (Netherlands). Research Inst. of Toxicology.
Mixed function oxidases ;
Enzyme induction ;
Polychlorobiphenyl compounds ;
Dose-response relationships ;
Liver microsomes ;
Metabolic activation ;
Water pollution effects(Animals) ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The influence of enzyme induction on the acute toxicity of aniline and 4-chloroaniline to rainbow trout (Salmo gairdneri) was investigated. For these two xenobiotics, bioactivation reactions are known to occur in mammals. Induction of cytochrome P450 mixed-function oxidase was obtained by intraperitoneal (ip) injection of trout with a mixture of polychlorinated biphenyls (Aroclor 1254). Five days after ip injection with three different doses of Aroclor 1254 (50, 100, and 200 mg/kg), benzo(a)pyrene hydroxylase activity in trout liver microsomes increased five- to sixfold. Cytochrome P450 concentrations in the microsomes were slightly, but significantly, enhanced in two of the three dose levels. The 96-hr LC50's of aniline and 4-chloroaniline were not affected by pretreatment with Aroclor 1254, suggesting that metabolic activation does not necessarily play a role in the acute toxicity of aromatic amines to fish. (Copyright (c) 1990 Academic Press, Inc.)
||Pub. in Ecotoxicology and Environmental Safety, v20 p156-166 1990. Prepared in cooperation with Utrecht Rijksuniversiteit (Netherlands). Research Inst. of Toxicology.
|NTIS Title Notes
||Reprint: Influence of Cytochrome P450 Mixed-Function Oxidase Induction on the Acute Toxicity to Rainbow Trout 'Salmo gairdner' of Primary Aromatic Amines.
||57Y; 57F; 68D
||PC A03/MF A01