Full Record Display for the EPA National Library Catalog

RECORD NUMBER: 47 OF 86

OLS Field Name OLS Field Data
Main Title Kinetics and Metabolism of Inhaled Methyl Chloroform (1,1,1-Trichloroethan) in Human Volunteers with Cover Letter.
CORP Author Dow Chemical Co., Midland, MI.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 28 Jun 1983
Year Published 1983
Report Number OTS-878213685;
Stock Number OTS-0206356
Additional Subjects Kinetics ; Metabolism ; Inhalation ; Chloroform ; Humans ; Males ; Lungs ; Exposure ; Toxicity ; Blood ; Air ; Rats ; Methyl chloroform(MC) ; Trichloroethanol(TCE) ; Trichloroacetic acid(TCA) ; 1,1,1,-Trichloroethane
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  OTS-0206356 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/29/2008
Collation 32p
Abstract The kinetics of inhaled methyl chloroform (MC) and its principal metabolites, trichloroethanol (TCE) and Trichloroacetic acid (TCA), were defined in 6 healthy male volunteers following single 6 hr exposures of 350 and 35 ppm. Blood and expired air MC concentrations were proportional to the exposure concentration and indicated about 25% of the MC inhaled during the 6 hr exposure was absorbed. Elimination of MC was tri-exponential with half-lives estimated as 44 min, 5.7. hr and 53 hr for the initial, intermediate and terminal phases. Over 91% of the absorbed MC was excreted unchanged via the lungs, 5-6% was metabolized and excreted as TCE and TCA, and less than 1% remained in the body after 9 days. Urinary TCE and TCA excretion were extremely variable and indicated that urinary TCE and TCA measurements provide at best only a rough estimate of the exposure. These data suggest that the kinetics of MC in man is essentially first-order at or below the current TLV of 350 ppm. Based on a comparison of the blood MC levels and amounts of MC metabolized, the rat is a better model than the mouse to predict the toxicity of MC in man.
Supplementary Notes The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC.
Availability Notes Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.
Category Codes 57Y; 57O
NTIS Prices PC A04/MF A01
Document Type NT
Cataloging Source NTIS/MT
Control Number 009401080
Origin NTIS
Type CAT