||Kinetics and Metabolism of Inhaled Methyl Chloroform (1,1,1-Trichloroethan) in Human Volunteers with Cover Letter.
||Dow Chemical Co., Midland, MI.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
||28 Jun 1983
Methyl chloroform(MC) ;
Trichloroacetic acid(TCA) ;
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||The kinetics of inhaled methyl chloroform (MC) and its principal metabolites, trichloroethanol (TCE) and Trichloroacetic acid (TCA), were defined in 6 healthy male volunteers following single 6 hr exposures of 350 and 35 ppm. Blood and expired air MC concentrations were proportional to the exposure concentration and indicated about 25% of the MC inhaled during the 6 hr exposure was absorbed. Elimination of MC was tri-exponential with half-lives estimated as 44 min, 5.7. hr and 53 hr for the initial, intermediate and terminal phases. Over 91% of the absorbed MC was excreted unchanged via the lungs, 5-6% was metabolized and excreted as TCE and TCA, and less than 1% remained in the body after 9 days. Urinary TCE and TCA excretion were extremely variable and indicated that urinary TCE and TCA measurements provide at best only a rough estimate of the exposure. These data suggest that the kinetics of MC in man is essentially first-order at or below the current TLV of 350 ppm. Based on a comparison of the blood MC levels and amounts of MC metabolized, the rat is a better model than the mouse to predict the toxicity of MC in man.
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