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OLS Field Name OLS Field Data
Main Title Biochemical Events during Initiation of Rat Hepatocarcinogenesis.
Author Dragan, Y. P. ; Hully, J. R. ; Nakamura, J. ; Mass, M. J. ; Swenberg, J. A. ;
CORP Author Wisconsin Univ.-Madison. McArdle Lab. for Cancer Research. ;North Carolina Univ. at Chapel Hill. Dept. of Pathology.;Health Effects Research Lab., Research Triangle Park, NC. Carcinogenesis and Metabolism Branch.;National Cancer Inst., Bethesda, MD.;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
Publisher c1994
Year Published 1994
Report Number EPA-R-816214 ;NCI-CA-07175; EPA/600/J-94/546;
Stock Number PB95-148086
Additional Subjects Biochemistry ; Carcinogenesis ; Liver ; Models ; Rats ; Cells(Biology) ; Tracer techniques ; Solvents ; Enzymes ; Neoplasms ; Reprints ; Trioctanoin
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NTIS  PB95-148086 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/06/1995
Collation 10p
Abstract Carcinogenesis is a multistep, multistage process that begins with irreversible, but heritable damage to a single cell. The partial hepatectomy/diethylnitrosamine (DEN) model of rat hepatocarcinogenesis has been well characterized and many aspects of the stage of initiation are known. In this manuscript male Fischer rats were subjected to a 70% partial hepatectomy and at the peak of cell proliferation 24 h later were adminsitered the solvent, trioctanoin, or 10 mg DEN/kg. The presence of 3 promutagenic adducts was seen during enhanced cellular proliferation and may contribute to the initiation that results in this model for hepatocarcinogenesis.
Supplementary Notes Pub. in Jnl. of Carcinogenesis 15, n7 p1451-1458 Jul 94. Prepared in cooperation with North Carolina Univ. at Chapel Hill. Dept. of Pathology. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Carcinogenesis and Metabolism Branch., National Cancer Inst., Bethesda, MD., and National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
Highlights Notes %AUT:H. C. /Pitot
NTIS Title Notes Journal article.
Title Annotations Reprint: Biochemical Events during Initiation of Rat Hepatocarcinogenesis.
Category Codes 57E
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 503414708
Origin NTIS
Type CAT