||Biochemical Events during Initiation of Rat Hepatocarcinogenesis.
Dragan, Y. P. ;
Hully, J. R. ;
Nakamura, J. ;
Mass, M. J. ;
Swenberg, J. A. ;
||Wisconsin Univ.-Madison. McArdle Lab. for Cancer Research. ;North Carolina Univ. at Chapel Hill. Dept. of Pathology.;Health Effects Research Lab., Research Triangle Park, NC. Carcinogenesis and Metabolism Branch.;National Cancer Inst., Bethesda, MD.;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
||EPA-R-816214 ;NCI-CA-07175; EPA/600/J-94/546;
Tracer techniques ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Carcinogenesis is a multistep, multistage process that begins with irreversible, but heritable damage to a single cell. The partial hepatectomy/diethylnitrosamine (DEN) model of rat hepatocarcinogenesis has been well characterized and many aspects of the stage of initiation are known. In this manuscript male Fischer rats were subjected to a 70% partial hepatectomy and at the peak of cell proliferation 24 h later were adminsitered the solvent, trioctanoin, or 10 mg DEN/kg. The presence of 3 promutagenic adducts was seen during enhanced cellular proliferation and may contribute to the initiation that results in this model for hepatocarcinogenesis.
||Pub. in Jnl. of Carcinogenesis 15, n7 p1451-1458 Jul 94. Prepared in cooperation with North Carolina Univ. at Chapel Hill. Dept. of Pathology. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Carcinogenesis and Metabolism Branch., National Cancer Inst., Bethesda, MD., and National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
||%AUT:H. C. /Pitot
|NTIS Title Notes
||Reprint: Biochemical Events during Initiation of Rat Hepatocarcinogenesis.
||PC A02/MF A01