Main Title |
Preliminary Report on the Concentration Time Response Relationships for Hydrogen Fluoride with Attachments and Cover Letter dated 06/21/88. |
CORP Author |
Du Pont de Nemours (E.I.) and Co., Wilmington, DE. Haskell Lab. for Toxicology and Industrial Medicine.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Publisher |
28 Jun 1988 |
Year Published |
1988 |
Report Number |
FYI-OTS-0788-0607; |
Stock Number |
OTS-0000607-1 |
Additional Subjects |
Hydrogen fluoride ;
Toxicity tests ;
Exposure time ;
Concentration ;
Lethality ;
LC50 ;
Relative humidity ;
Rats ;
Health effects ;
Respiratory distress ;
DuPont(Tradmark)
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Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS-0000607-1 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
29p |
Abstract |
The acute toxicity of hydrogen fluoride (HF) was evaluated in a series of experiments to determine the relationships between exposure time, HF concentration and lethality. Groups of 4 male Crl:CD(trademark)BR rats (approx. 200-300 g) were inserted into a 23 L Lucite(trademark) exposure chamber and exposed head-only to atmospheres of HF for periods of 5, 15, 30 or 60 minutes. Exposures were initially conducted with gaseous HF (2% HF in nitrogen) but due to the limited commercial availability of 2% HF, further exposures were performed using liquefied anhydrous HF. Anhydrous HF was diluted in either dry (les than 10% relative humidity) or humid (40-60% relative humidity) air. Gas samples were collected from the exposure chamber using tandem midget impingers and fluoride concentrations were measured with a fluoride ion selective electrode. Although body weights and clinical signs of toxicity were recorded during a 2-week recovery period, lethality was the primary endpoint for these studies. Mortality data were obtained from 6-15 exposures per time point and LC50 values were calculated by probit analysis. |
Supplementary Notes |
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Availability Notes |
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Category Codes |
57Y; 57U; 57B; 68G; 99D |
NTIS Prices |
PC A03/MF$25.00 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
019102900 |
Origin |
NTIS |
Type |
CAT |