Full Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Preliminary Report on the Concentration Time Response Relationships for Hydrogen Fluoride with Attachments and Cover Letter dated 06/21/88.
CORP Author Du Pont de Nemours (E.I.) and Co., Wilmington, DE. Haskell Lab. for Toxicology and Industrial Medicine.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 28 Jun 1988
Year Published 1988
Report Number FYI-OTS-0788-0607;
Stock Number OTS-0000607-1
Additional Subjects Hydrogen fluoride ; Toxicity tests ; Exposure time ; Concentration ; Lethality ; LC50 ; Relative humidity ; Rats ; Health effects ; Respiratory distress ; DuPont(Tradmark)
Library Call Number Additional Info Location Last
NTIS  OTS-0000607-1 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 10/08/2007
Collation 29p
Abstract The acute toxicity of hydrogen fluoride (HF) was evaluated in a series of experiments to determine the relationships between exposure time, HF concentration and lethality. Groups of 4 male Crl:CD(trademark)BR rats (approx. 200-300 g) were inserted into a 23 L Lucite(trademark) exposure chamber and exposed head-only to atmospheres of HF for periods of 5, 15, 30 or 60 minutes. Exposures were initially conducted with gaseous HF (2% HF in nitrogen) but due to the limited commercial availability of 2% HF, further exposures were performed using liquefied anhydrous HF. Anhydrous HF was diluted in either dry (les than 10% relative humidity) or humid (40-60% relative humidity) air. Gas samples were collected from the exposure chamber using tandem midget impingers and fluoride concentrations were measured with a fluoride ion selective electrode. Although body weights and clinical signs of toxicity were recorded during a 2-week recovery period, lethality was the primary endpoint for these studies. Mortality data were obtained from 6-15 exposures per time point and LC50 values were calculated by probit analysis.
Supplementary Notes The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC.
Availability Notes Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.
Category Codes 57Y; 57U; 57B; 68G; 99D
NTIS Prices PC A03/MF$25.00
Document Type NT
Cataloging Source NTIS/MT
Control Number 019102900
Origin NTIS
Type CAT