||Initial Submission: Summary of Toxicokinetic Studies on Bis(Tributyltin) Oxide (TBTO) Performed at Schering with Cover Letter dated 09/29/1992.
||Schering AG.; Elf Atochem North America, Philadelphia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Tributyltin oxide ;
Acute toxicity ;
Pharmaco kinetics ;
Tissue concentration ;
CAS No 56-35-9
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Four groups of each 5 male rats received a daily dose of 5 mg TBTO/kg as aqueous suspension once, three times, 7 times, and 14 times, respectively. Organ and tissue specimens were removed in each case 24 hours after the single (last) dose. Urine and feces were collected in daily frac- tions in that group of animals treated for 14 days. As was shown by a preexperiment in bile duct cannulated animals only about 20 % of TBTO dose administered was absorbed in this study. Excluding the radioactivity located in the gastro-intestinal tract (GIT), on an average 12 + or - 2 % of the administered dose was detectable in the animal bodies 24 hours after i.g. administration.
||The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
||Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at firstname.lastname@example.org. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.
|PUB Date Free Form
||13 Oct 1992
||57Y; 57U; 68G; 99; 44G
||PC A04/MF A04