Main Title |
Toxicity Studies with Decamethrin, A Synthetic Pyrethroid Insecticide. |
Author |
Kavlock, R. ;
Chernoff, N. ;
Baron, R. ;
Dilley, J. ;
Simmon, V. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. |
Year Published |
1978 |
Report Number |
EPA/600/J-79/036; |
Stock Number |
PB80-124431 |
Additional Subjects |
Toxicology ;
Pesticides ;
Nitrogen organic compounds ;
Insecticides ;
Rats ;
Bioassay ;
Lethal dosage ;
Concentration(Composition) ;
Ingestion(Biology) ;
Parenteral infusions ;
Sex ;
Age ;
Signs and symptoms ;
In vitro analysis ;
Reprints ;
Decamethrin ;
Toxic substances ;
Cyclopropane carboxylic acid/cyano-phenoxybenzyl-(dibromovinyl)-dimethyl
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB80-124431 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
17p |
Abstract |
Decamethrin is a synthetic pyrethroid insecticide that has been under investigation by the World Health Organization for use in some vector control programs. Decamethrin proved to be a highly toxic pyrethroid ester. The acute LD50 for adult female rats was 31 mg/kg by the oral route and 4 mg/kg by the intravenous route of administration. The LD50 was observed to be sex and age dependent, with higher values recorded for weanlings and males. Initial signs of decamethrin poisoning included profuse salivation and convulsive movements. Weakness, dyspnea, anorexia and staining of the fur were observed beyond the first day following compound administration. Absorption of decamethrin was rapid by the inhalation route and minimal by the dermal route of administration. No evidence of teratogenic activity was found in rats or mice at dose levels that produced marked maternal toxicity, and no persistent toxicity was observed in neonatal rats that received perinatal exposure to decamethrin. No mutagenic activity was detected in three different in vitro assays, with or without metabolic activation. |
Supplementary Notes |
Pub. in Jnl. of Environmental Pathology and Toxicology, v2 p751-765 1979. Prepared in cooperation with SRI International, Menlo Park, CA. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Toxicity Studies with Decamethrin, A Snythetic Pyrethroid Insecticide. |
PUB Date Free Form |
11 Sep 78 |
Category Codes |
6T; 6F; 57Y; 68E |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
323772431 |
Origin |
NTIS |
Type |
CAT |