||Effect of insecticides on benzo(a)pyrene carcinogenesis /
Triolo, Anthony J.
||Jefferson Medical Coll., Philadelphia, PA.;Health Effects Research Lab., Research Triangle Park, NC.
|| U.S. Environmental Protection Agency, Health Effects Research Laboratory,
Aromatic polycyclic hydrocarbons ;
Phosphorus organic compounds ;
Laboratory animals ;
Experimental data ;
Chlorine organic compounds ;
Carbamic acid/methyl-(naphthyl-ester) ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||vi, 32 pages ; 28 cm.
||The pesticides parathion, toxaphene, and carbaryl were tested for their ability to induce tumors in the forestomach and lungs of female Ha/ICR and A/J mice respectively. None of these pesticides, when fed alone in the diet of the mice, showed significant oncogenic activity. On the other hand, toxaphene enhanced benzo(a)pyrene (BP)-induced tumors and increased BP hydroxylase activity in the forestomach of the Ha/ICR mice and carbaryl enhanced BP-induced tumors and increased BP hydroxylase activity in the lungs of the A/J mice. In each instance, it is possible that toxaphene and carbaryl exhibited a cooncogenic effect in enhancing the BP-induced tumors. Conversely, toxaphene decreased the incidence of BP-induced tumors and inhibited BP hydroxylase activity in the lungs of the A/J mice. These results suggest that increased BP hydroxylase activity in tissues tends to enhance tumor formation and a decrease in the enzyme activity may have a protective effect agains tumors. The relationship between enzyme inducibility and tumor formation may be due to the level of oncogenic epoxides formed in target organs. Further, studies of the formation of specific oncogenic epoxides of BP in tissues after treatment with these pesticides would help towards defining more clearly the relationship between BP hydroxylase inducibility and BP oncogenesis.
||"EPA-600/1-78-066." Includes bibliographical references (pages 28-31). Microfiche.
||Research Triangle Park, NC :
|Corporate Au Added Ent
||Health Effects Research Laboratory (Research Triangle Park, N.C.) ; United States. Environmental Protection Agency. Office of Research and Development. ; Jefferson Medical College.
|Title Ser Add Ent
||Research reporting series Environmental health effects research ;
|PUB Date Free Form
|Series Title Untraced
||Environmental health effects research series ; EPA 600/1-78/066
||PC A03/MF A01
|OCLC Time Stamp
|OCLC Rec Leader
||01263nam 2200301Ka 45020