Main Title |
Glucocorticoids Regulate the Synthesis of Glial Fibrillary Acidic Protein in Intact and Adrenalectomized Rats but Do Not Affect Its Expression Following Brain Injury. |
Author |
O'Callaghan, J. P. ;
Brinton, R. E. ;
McEwen, B. S. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Rockefeller Univ., New York. |
Publisher |
c1991 |
Year Published |
1991 |
Report Number |
EPA/600/J-91/212; |
Stock Number |
PB91-243030 |
Additional Subjects |
Glucocorticoids ;
Glial fibrillary acidic protein ;
Adrenalectomy ;
Stains and staining ;
Rats ;
Hippocampus ;
Cerebral cortex ;
Steroids ;
Microtubule-associated proteins ;
Deoxyribonucleic acids ;
Radioimmunoassay ;
Trimethyltin ;
mRNA ;
Northern blotting ;
Immunohistochemistry ;
Brain injuries ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB91-243030 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
12p |
Abstract |
Short (5 days)-to long-term (4 months) corticosterone (CORT) administration by injection, pellet implantation, or in the drinking water decreased glial fibrillary acidic protein (GFAP) by 20-40% in hippocampus and cortex of intact rats. In contrast to CORT, adrenalectomy (ADX) caused elevations (50-125%) in hippocampus and cortex GFAP within 12 days of surgery that persisted for at least 4 months. CORT replacement of ADX rats decreased GFAP amount in hippocampus and cortex. The effects of long-term CORT and ADX on GFAP in hippocampus and cortex were also seen in striatum, midbrain, and cerebellum, findings suggestive of brain-wide adrenal steroid regulation of the astrocyte protein. The changes in GFAP amount due to CORT and ADX were paralleled by changes in GFAP mRNA, indicating a possible transcriptional or at least genomic effect of adrenal steroids. (Copyright (c) 1991 International Society for Neurochemistry.) |
Supplementary Notes |
Pub. in Jnl. of Neurochemistry, v57 n3 p860-869 Sep 91. Prepared in cooperation with Rockefeller Univ., New York. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Glucocorticoids Regulate the Synthesis of Glial Fibrillary Acidic Protein in Intact and Adrenalectomized Rats but Do Not Affect Its Expression Following Brain Injury. |
Category Codes |
57Q; 57B; 57S; 57X |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
131122051 |
Origin |
NTIS |
Type |
CAT |