||Storage and Excretion of DDT in Starved Rats.
Dale, William E. ;
Gaines, Thomas B. ;
Hayes, Jr., Wayland J. ;
||Communicable Disease Center, Atlanta, Ga.
Laboratory animals ;
Experimental data ;
Body weight ;
Pesticide residues ;
Toxic substances ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||It is well known that some poisons, such as lead when stored in sufficient amount, may be mobilized from storage with the result that clinical illness appears or recurs. This phenomenon was first demonstrated experimentally for DDT by Fitzhugh and Nelson (1947). They showed that rats that had been fed diets containing DDT at concentrations of 600 parts per million (ppm) or more showed marked tremors when they were deprived of food completely. Rats deprived of all food after being fed 200 or 400 ppm showed increased irritability but no tremors. It has been assumed that these clinical effects resulted from a mobilization of DDT concurrent with the mobilization of body fat, but the effect of starvation on the concentration of DDT in various tissues and excreta has not previously been measured. This paper reports the results of such measurements in rats that were starved and in suitable controls. The results confirm that DDT is, in fact, mobilized into the circulation and into the brain during starvation and thus explain the clinical effects.
||Pub. in Toxicology and Applied Pharmacology, v4 n1 p89-106, Jan 62.
||Included in the report, Journal Articles on Toxicology. Group 9, PB-279 718.
||Reprint: Storage and Excretion of DDT in Starved Rats,
|PUB Date Free Form
||3 Jul 61
||6T; 57Y; 68G; 68E
||(Order as PB-279 718, MF A01)