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OLS Field Name OLS Field Data
Main Title Storage and Excretion of DDT in Starved Rats.
Author Dale, William E. ; Gaines, Thomas B. ; Hayes, Jr., Wayland J. ;
CORP Author Communicable Disease Center, Atlanta, Ga.
Year Published 1961
Stock Number PB-279 726
Additional Subjects Insecticides ; DDT ; Pesticides ; Toxicology ; Bioassay ; Rats ; Laboratory animals ; Storage ; Excretion ; Experimental data ; Dosage ; Concentration(Composition) ; Brain ; Circulation ; Starvation ; Body weight ; Tissues(Biology) ; Tables(Data) ; Reprints ; Pesticide residues ; Bioaccumulation ; Toxic substances ; Metabolites ; Adipose tissue
Library Call Number Additional Info Location Last
NTIS  PB-279 726 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 10p
Abstract It is well known that some poisons, such as lead when stored in sufficient amount, may be mobilized from storage with the result that clinical illness appears or recurs. This phenomenon was first demonstrated experimentally for DDT by Fitzhugh and Nelson (1947). They showed that rats that had been fed diets containing DDT at concentrations of 600 parts per million (ppm) or more showed marked tremors when they were deprived of food completely. Rats deprived of all food after being fed 200 or 400 ppm showed increased irritability but no tremors. It has been assumed that these clinical effects resulted from a mobilization of DDT concurrent with the mobilization of body fat, but the effect of starvation on the concentration of DDT in various tissues and excreta has not previously been measured. This paper reports the results of such measurements in rats that were starved and in suitable controls. The results confirm that DDT is, in fact, mobilized into the circulation and into the brain during starvation and thus explain the clinical effects.
Supplementary Notes Pub. in Toxicology and Applied Pharmacology, v4 n1 p89-106, Jan 62.
Availability Notes Included in the report, Journal Articles on Toxicology. Group 9, PB-279 718.
Title Annotations Reprint: Storage and Excretion of DDT in Starved Rats,
PUB Date Free Form 3 Jul 61
Category Codes 6T; 57Y; 68G; 68E
NTIS Prices (Order as PB-279 718, MF A01)
Primary Description 500/01
Document Type NT
Cataloging Source NTIS/MT
Control Number 323738924
Origin NTIS
Type CAT