Main Title |
Statistical Relationships between Exposure and Dose. |
Author |
Mage, D. T. ;
|
CORP Author |
Environmental Monitoring Systems Lab., Research Triangle Park, NC. |
Year Published |
1984 |
Report Number |
EPA/600/D-84/274; |
Stock Number |
PB85-124675 |
Additional Subjects |
Air pollution ;
Statistical analysis ;
Dosage ;
Public health ;
Mathematical models ;
Exposure ;
Monte Carlo method ;
Hazardous materials ;
Air pollution effects(Humans) ;
Air quality ;
Numerical solution
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB85-124675 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
13p |
Abstract |
The health effects of pollutants are often modeled by a dose-response relationship where the dose may be the mass of the pollutant delivered to a target body compartment. Since the dosage cannot be measured, the subject's personal exposure or the ambient exposure is often used as surrogates for the dosage. As shown by derivations and simulations, the usage of personal exposure as a surrogate for dosage leads to an unbiased relationship. Since the use of ambient exposure as a surrogate for personal exposure can be treated as an observation of the personal exposure with measurement error, the use of ambient exposure as a surrogate for dosage leads to a biased estimate of dose-response effect. The simulations show that personal exposure as a surrogate for dosage can lead to an increased variance of the regression coefficients relating the measured responses to the scaled dosage. |
PUB Date Free Form |
Nov 84 |
Category Codes |
6E; 6T; 68G; 68A; 57U; 57Y |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/08 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
504625836 |
Origin |
NTIS |
Type |
CAT |