| Main Title |
Mixtures of Volatile Organic Compounds: Detection of Odor, Nasal Pungency, and Eye Irritation. |
| Author |
Cometto-Muniz, J. E. ;
Cain, W. S. ;
|
| CORP Author |
California Univ., San Diego, La Jolla. Dept. of Surgery. ;John B. Pierce Foundation Lab., New Haven, CT.;Environmental Protection Agency, Research Triangle Park, NC. Air Pollution Prevention and Control Div.;National Institutes of Health, Bethesda, MD. |
| Publisher |
1997 |
| Year Published |
1997 |
| Report Number |
EPA-R-816362-02 ;NIH-DC00284; EPA/600/A-97/042; |
| Stock Number |
PB97-193684 |
| Additional Subjects |
Organic compounds ;
Smell ;
Odors ;
Pollution control ;
Measurement ;
Olfactory nerves ;
Senses ;
Volatile organic compounds ;
Eye irritation ;
Trigeminal nerves
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB97-193684 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
16p |
| Abstract |
The paper gives results of the measurement of threshold responses of odor, nasal pungency (irritation), and eye irritation for single chemicals (1-oropanol, 1-hexanol, ethyl acetate, heptyl acetate, 2-pentanone, toluene, ethyl benzene, and propyl benzene), and their mixtures (two three-component mixtures, two six-component mixtures, and one nine-component mixture). Nasal pungency was measured in subjects lacking a functional sense of smell (i.e., anosmics) to avoid interference from olfaction. Various degrees of stimulus agonism (additive effects) were observed for each of the three sensory channels when testing mixtures. As the number of components and the lipophilicity of such components in the mixtures increased, so did the degree of agonism. Synergistic stimulus agonism characterized the eye irritation response for the most complex (the nine-component) and the most lipophilic (one of the six-component) mixtures. Physicochemical properties play a large role in the determination of sensitivity to airborne chemicals, particularly to their ability to evoke irritation. Whereas this has revealed itself previously with respect to single chemicals, it seems to have relevance to mixtures as well. |
| Supplementary Notes |
Presented at Healthy Buildings '95, Milan, Italy, September 10-14, 1995. Prepared in cooperation with John B. Pierce Foundation Lab., New Haven, CT. Sponsored by Environmental Protection Agency, Research Triangle Park, NC. Air Pollution Prevention and Control Div. and National Institutes of Health, Bethesda, MD. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)321-8547; and email at orders@ntis.fedworld.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| NTIS Title Notes |
Proceedings. |
| Category Codes |
57Y; 68A |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/13 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
731601200 |
| Origin |
NTIS |
| Type |
CAT |
