Main Title |
Assessment of Host Resistance to 'Trichinella spiralis' in Mice Following Preinfection Exposure to 2,3,7,8-TCDD. |
Author |
Luebke, R. W. ;
Copeland, C. B. ;
Diliberto, J. J. ;
Akubue, P. I. ;
Andrews, D. L. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC. |
Publisher |
c1994 |
Year Published |
1994 |
Report Number |
EPA/600/J-94/404; |
Stock Number |
PB95-125423 |
Additional Subjects |
Trichinella spiralis ;
Tetrachlorodibenzo dioxin ;
Toxicology ;
Natural immunity ;
Mice ;
Larvae ;
Cell division ;
Body weight ;
Spleen ;
Thymus gland ;
Organ weight ;
Small intestine ;
Sensitivity and specificity ;
Antigens ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB95-125423 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
14p |
Abstract |
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been reported to decrease host resistance to a variety of infectious agents when exposure occurs prior to infection. In the present study, female B6C3F1 mice were exposed to a single intraperitoneal injection of 0, 0.1, 1.0, 10.0, or 30.0 micrograms TCDD/kg 7 days prior to infection to determine the effects of TCDD exposure on resistance to the nematode parasite Trichinella spiralis. Exposure to 10 or 30 micrograms TCDD/kg delayed adult parasite elimination from the small intestine. Significantly more larvae were released by female parasites and greater numbers of encysted larvae were recovered from the muscle of mice exposed to TCDD. These results, particularly correlating TCDD dose to spenocyte and lymph node cell proliferation, suggest an interaction between TCDD exposure and infection, i.e., that exposure to TCDD altered the host response to infection, while infection delayed elimination of TCDD from the host. |
Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology 125, n1 p7-16 Mar 94. Prepared in cooperation with ManTech Environmental Technology, Inc., Research Triangle Park, NC. |
Highlights Notes |
%AUT:M. M. /Riddle ;W. C. /Williams ;L. S. /Birnbaum |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Assessment of Host Resistance to 'Trichinella spiralis' in Mice Following Preinfection Exposure to 2,3,7,8-TCDD. |
Category Codes |
57N; 57Y |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
435317925 |
Origin |
NTIS |
Type |
CAT |