||Initial Submission: Letter from Dupont Chemical to USEPA regarding Embryo-Fetal and Terotogenicity Study of Silane in Rats with Cover Letter and Attachments dated 08/20/1992.
||Du Pont de Nemours (E.I.) and Co., Wilmington, DE.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Toxic substances ;
Silane(bis(4- fluropheny))(methyl) (1H-1 ;
Fertility effects ;
Combined teratogenicity ;
Reproductive effects ;
CAS No 85509-19-9
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Rats were dosed at levels of 0, 10, 50, and 250 mg/kg; maternal toxicity and deaths occurred at 250 mg/kg; a significant increase in the incidence of fetuses with cleft palate and with absence of renal papilla was seen at 250 mg/kg. Embryo-fetal toxicity was noted at all levels tested (decreased fetal weight, increased fetal death at 250 mg/kg; and increase incidence of skeletal variations at 10 mg/kg and above).
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|PUB Date Free Form
||24 Aug 1992
||57Y; 57U; 68G; 99; 44G
||PC A03/MF A03