||Silicone A-187 Seven-Day Rabbit Skin Inunction during Seventeen Calendar Days with Cover Letter.
||Union Carbide Corp., Danbury, CT.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
||5 May 1975
Laboratory animals ;
Organo-silane ester ;
Body weight ;
Liver weight ;
Kidney weight ;
Silicone A-187 ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||A group of four male albino rabbits received 7 inunctions of Silicone A-187 over a period of 17 calendar days. The dosage level was 1.0 ml/kg. A shared control group was inuncted with 2.0 ml/kg of distilled water and served as the control for dosages of both 1 and 2 ml/kg. The dosed group was statistically equivalent to the control group in all criteria of stress examined, namely: mortality, body weight change, liver and kidney weight per se and as percentage of body weight. Therefore, the no ill-effect level for a 7-day inunction of Silicone A-187 on rabbits is greater than 1.0 ml/kg/inunction.
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||PC A08/MF A02