||Evaluation of Sensory System Function Using Reflex Modification of the Startle Response.
Crofton, K. M. ;
Sheets., L. P. ;
||Health Effects Research Lab., Research Triangle Park, NC.
Public health ;
Chemical compounds ;
Environmental surveys ;
Nervous system disorders ;
Toxic substances ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Methods to measure damage to sensory systems following toxicant exposure vary from rapid and subjective tests (e.g., pinna reflex) to time-consuming and objective tests (e.g., psychophysical tests). Reflex modification of the startle response represents an alternative technique in the assessment of sensory function. Advantages of this procedure include: no prior training requirements, rapid and objective measurement of sensory thresholds, ability to differentiate sensory from non-sensory damage, and potential for predictive validity. This procedure has also been shown to be sensitive to a variety of neurotoxic compounds. Future research should concentrate on demonstrating the research potential of this technique for use in neurotoxicology.
||Pub. in Jnl. of the American College of Toxicology, v8 n1 p199-211 Mar 89.
|NTIS Title Notes
||Reprint: Evaluation of Sensory System Function Using Reflex Modification of the Startle Response.
||68G; 57U; 57S; 57Y
||PC A03/MF A01