Main Title |
Effects of Metal Cations on Pituitary Hormone Secretion In vitro (Journal Version). |
Author |
Cooper, R. L. ;
Goldman, J. M. ;
Rehnberg, G. L. ;
McElroy, W. K. ;
Hein, J. F. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1987 |
Year Published |
1987 |
Report Number |
EPA/600/J-87/401; |
Stock Number |
PB89-106439 |
Additional Subjects |
Nickel ;
Cadmium ;
Zinc ;
Pituitary hormones ;
Laboratory animals ;
Secretion ;
Prolactin ;
Thyrotropin ;
LH ;
Toxicology ;
Metals ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB89-106439 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
12p |
Abstract |
The purpose of the study was to determine, in vitro, the effects of nickel, cadmium, and zinc (50 microM) on both baseline and potassium chloride (KCl)-stimulated pituitary luteinizing hormone (LH), prolactin (Prl), and thyroid-stimulating hormone (TSH) release. Baseline and stimulated LH releases were unaffected by nickel and zinc; however, cadmium caused an increase in baseline LH secretion. Baseline Prl release was decreased by zinc, while cadmium resulted in increased release of the hormone. Stimulated Prl release was lower during exposure to zinc but unaltered by nickel and cadmium. Following exposure to zinc, a rebound in stimulated release was noted for all three hormones measured. These results showed that the metal cations tested did have a direct effect on pituitary hormone release at a dose lower than those reported to alter testicular function in vitro. Furthermore, the changes in pituitary hormone secretion varied depending upon the metal and hormone being evaluated. (Copyright (c) VCH Publishers, Inc.) |
Supplementary Notes |
Pub. in Jnl. of Biochemical Toxicology, v2 p241-249 1987. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Effects of Metal Cations on Pituitary Hormone Secretion In vitro (Journal Version). |
Category Codes |
57Y |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
834422262 |
Origin |
NTIS |
Type |
CAT |