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OLS Field Name OLS Field Data
Main Title Allergic response to platinum and palladium complexes : determination of no-effect level /
Author Taubler, James.
CORP Author Saint Vincent Coll., Latrobe, Pa. Dept. of Biology.;Health Effects Research Lab., Research Triangle Park, N.C.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Library ; National Technical Information Service [distributor] ;
Year Published 1977
Report Number EPA/600/1-77/039; EPA-R-803036
Stock Number PB-271 659
OCLC Number 53336302
Subjects Platinum--Toxicology. ; Palladium--Toxicology. ; Allergy--Research.
Additional Subjects Platinum ; Palladium ; Allergic diseases ; Immunologic diseases ; Bioassay ; Laboratory animals ; Rabbits ; Guinea pigs ; Mice ; Dosage ; Injections(Medicine) ; Skin(Anatomy) ; Industrial atmospheres ; Catalytic converters ; Air pollution ; Responses ; Contact dermatitis ; Health risks ; Environmental health
Library Call Number Additional Info Location Last
NTIS  PB-271 659 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation v, 82 pages ; 28 cm.
Abstract Rabbits, guinea pigs and mice were subcutaneously injected with PtSO4 (with and without NH4Cl) and PdSO4 (with and without NH4Cl) in an attempt to sensitize the animals to platinum or palladium. No allergic induction was found. No allergic induction to platinum or palladium was found in rabbits, guinea pigs or mice when these animals were injected intravenously with platinum or palladium. Dermal contact with platinum was also tested on rabbits and guinea pigs but failed to induce an allergic state. Platinum and palladium levels in the sera, urine and spleens of the animals, as monitored by AAS, were not significant. Rabbits, guinea pigs and mice were intravenously or subcutaneously injected with a platinum-egg albumin complex or a palladium-egg albumin complex. Skin tests or footpad tests were performed 10-14 days after the last intravenous or subcutaneous injection. Only guinea pigs injected subcutaneously with palladium-egg albumin complex developed a hypersensitivity of the delayed type. A delayed type allergy was induced in guinea pigs subcutaneously injected with palladium complexed to egg albumin.
Notes "EPA-600/1-77-039." EPA grant no. 803036. EPA project officer: Robert M. Bruce. Includes bibliographical references (page 31). Microfiche.
Place Published Research Triangle Park, N.C. :
Corporate Au Added Ent Health Effects Research Laboratory (U.S.). ; United States. Environmental Protection Agency. Office of Research and Development. ; St. Vincent College.
Title Ser Add Ent Research reporting series Environmental health effects research series;
Series Title Traced Environmental health effects research series ; EPA-600/1-77-039
NTIS Prices PC A05/MF A01
BIB Level m
Cataloging Source OCLC/T
OCLC Time Stamp 20031103133152
Language eng
Origin OCLC
OCLC Rec Leader 01523nam 2200349Ka 45020