||Allergic response to platinum and palladium complexes : determination of no-effect level /
||Saint Vincent Coll., Latrobe, Pa. Dept. of Biology.;Health Effects Research Lab., Research Triangle Park, N.C.
|| U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Library ; National Technical Information Service [distributor] ;
Allergic diseases ;
Immunologic diseases ;
Laboratory animals ;
Guinea pigs ;
Industrial atmospheres ;
Catalytic converters ;
Air pollution ;
Contact dermatitis ;
Health risks ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||v, 82 pages ; 28 cm.
||Rabbits, guinea pigs and mice were subcutaneously injected with PtSO4 (with and without NH4Cl) and PdSO4 (with and without NH4Cl) in an attempt to sensitize the animals to platinum or palladium. No allergic induction was found. No allergic induction to platinum or palladium was found in rabbits, guinea pigs or mice when these animals were injected intravenously with platinum or palladium. Dermal contact with platinum was also tested on rabbits and guinea pigs but failed to induce an allergic state. Platinum and palladium levels in the sera, urine and spleens of the animals, as monitored by AAS, were not significant. Rabbits, guinea pigs and mice were intravenously or subcutaneously injected with a platinum-egg albumin complex or a palladium-egg albumin complex. Skin tests or footpad tests were performed 10-14 days after the last intravenous or subcutaneous injection. Only guinea pigs injected subcutaneously with palladium-egg albumin complex developed a hypersensitivity of the delayed type. A delayed type allergy was induced in guinea pigs subcutaneously injected with palladium complexed to egg albumin.
||"EPA-600/1-77-039." EPA grant no. 803036. EPA project officer: Robert M. Bruce. Includes bibliographical references (page 31). Microfiche.
||Research Triangle Park, N.C. :
|Corporate Au Added Ent
||Health Effects Research Laboratory (U.S.). ; United States. Environmental Protection Agency. Office of Research and Development. ; St. Vincent College.
|Title Ser Add Ent
||Research reporting series Environmental health effects research series;
|Series Title Traced
||Environmental health effects research series ; EPA-600/1-77-039
||PC A05/MF A01
|OCLC Time Stamp
|OCLC Rec Leader
||01523nam 2200349Ka 45020