| Main Title |
Review of the Mutagenicity of Chloroform. |
| Author |
Rosenthal, S. L. ;
|
| CORP Author |
Environmental Protection Agency, Washington, DC. Reproductive Effects Assessment Group. |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/241; |
| Stock Number |
PB88-169040 |
| Additional Subjects |
Toxicology ;
Review ;
Reprints ;
Chloroform ;
Mutagenesis ;
Genotoxicity
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-169040 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
18p |
| Abstract |
Although chloroform (CHCl3) is metabolized in vivo and in vitro to a substance that covalently interacts with protein and lipid, its potential for binding to DNA is low. In addition, most of the assays for genotoxicity are negative. However, many of the genotoxicity results are inconclusive because of inadequacies in the experimental protocols. The types of genotoxicity tests this report is based on include bacterial, yeast, host-mediated, Drosophila sex-linked recessive lethal, mammalian cell mutagenicity, sperm head abnormality, cytogenetic, and DNA damage. On the basis of presently available information, no definitive conclusion on the mutagenic potential of CHCl3 can be reached. |
| Supplementary Notes |
Pub. in Environmental and Molecular Mutagenesis, v10 p211-226 1987. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Review of the Mutagenicity of Chloroform. |
| PUB Date Free Form |
1987 |
| Category Codes |
57Y; 57O |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/21 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
812722078 |
| Origin |
NTIS |
| Type |
CAT |
