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RECORD NUMBER: 73 OF 2578

OLS Field Name OLS Field Data
Main Title Age-Dependent Pulmonary Response of Rats to Ozone Exposure.
Author Elsayed, N. M. ; Mustafa, M. G. ; Postlethwait, E. M. ;
CORP Author California Univ., Los Angeles. Center for the Health Sciences.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1982
Report Number EPA-R-806652; EPA-600/J-80-188;
Stock Number PB84-197599
Additional Subjects Ozone ; Toxicology ; Rats ; Exposure ; Response ; Laboratory animals ; Age ; Reprints ;
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NTIS  PB84-197599 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 17p
Abstract The influence of age on O3 effects in the lung was studied in 8 groups of Sprague-Dawley rats: 7, 12, and 18 d of age (neonatal); 24, 30, and 45 d of age (infant); and 60 and 90 d of age (adult). Lung weight, total lung protein and DNA contents, and a series of marker enzyme activities in lung tissue were determined. After exposure of rats from each group to 0.8 ppm (1568 micrograms/cu. m.) 03 continuously for 3 d, a biphasic effect was noted. The biochemical parameters, expressed per lung, in 03-exposed rats relative to their corresponding controls decreased in the 7 and 12 d old groups, increased or remained unchanged in the 18 d old group, and increased in the 24 to 90 d old groups. However, the increases were much greater for 60 to 90 d old rats than for 24 to 30 d old rats. The increase in lung biochemical parameters is thought to occur in response to lung injury and subsequent repair processes, and greater increases in the lungs of older rats suggest that they are more responsive to 03 exposure than younger rats. The decrease in lung biochemical parameters and increased mortality in 7 and 24 d old neonatal rats suggest that they are more susceptible to 03 stress than infant and adult rats.
Availability Notes Pub. in Jnl. of Toxicology and Environmental Health 9, p835-848 1982.
NTIS Title Notes Journal article.
Title Annotations Reprint: Age-Dependent Pulmonary Response of Rats to Ozone Exposure.
PUB Date Free Form c1982
Category Codes 6T; 57Y
NTIS Prices Not available NTIS
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 423020821
Origin NTIS
Type CAT