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RECORD NUMBER: 63 OF 2579

OLS Field Name OLS Field Data
Main Title Acute, 14-Day Repeated Dosing, and 90-Day Subchronic Toxicity Studies of Potassium Picloram (Journal Version).
Author Hayes, J. R. ; Condie, L. W. ; Borzelleca, J. F. ;
CORP Author Virginia Commonwealth Univ., Richmond. Dept. of Pharmacology and Toxicology.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1986
Year Published 1986
Report Number EPA-R-808861; EPA/600/J-86/473;
Stock Number PB89-103998
Additional Subjects Toxic substances ; Toxicity ; Herbicides ; Picloram ; Mortality ; Laboratory animals ; Dose-response relationships ; Oral administration ; Pathology ; Central nervous system ; Liver ; Kidney ; Reprints ; Picolinic acid/amino-trichloro(Potassium salt)
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NTIS  PB89-103998 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/14/1989
Collation 10p
Abstract Potassium picloram was administered either by gavage (acute studies) or in drinking water to male and female Sprague-Dawley derived rats (14-day and 90-day studies). The acute oral LD50 was 950 mg/kg (812-1120) for males and 686 mg/kg (599-786) for females. Depression, prostration, ataxia, tremors and convulsions preceded death. There were no consistent biologically significant compound related effects in rats that received 60, 190 or 600 mg potassium picloram/kg/day for 14 days. In the subchronic study, rats received 60, 190, 600 or 1070 mg potassium picloram/kg/day for 90 consecutive days. There were only 4 male and 2 female survivors out of 20 rats of each sex at the 1070 mg/kg dose and 16 male and 18 female survivors at the 570 mg/kg dose. Mortality was dose-dependent. No specific organ site toxicity could be identified in these studies. Toxicity from exposure to picloram in drinking water is apparently low. (Copyright (c) 1986 by the Society of Toxicology.)
Supplementary Notes Pub. in Fundamental and Applied Toxicology, v7 n3 p464-470 Oct 86. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Acute, 14-Day Repeated Dosing, and 90-Day Subchronic Toxicity Studies of Potassium Picloram (Journal Version).
Category Codes 57Y; 57U; 44G; 68E; 68G
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 833026567
Origin NTIS
Type CAT