||Acute, 14-Day Repeated Dosing, and 90-Day Subchronic Toxicity Studies of Potassium Picloram (Journal Version).
Hayes, J. R. ;
Condie, L. W. ;
Borzelleca, J. F. ;
||Virginia Commonwealth Univ., Richmond. Dept. of Pharmacology and Toxicology.;Health Effects Research Lab., Research Triangle Park, NC.
Toxic substances ;
Laboratory animals ;
Dose-response relationships ;
Oral administration ;
Central nervous system ;
Picolinic acid/amino-trichloro(Potassium salt)
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Potassium picloram was administered either by gavage (acute studies) or in drinking water to male and female Sprague-Dawley derived rats (14-day and 90-day studies). The acute oral LD50 was 950 mg/kg (812-1120) for males and 686 mg/kg (599-786) for females. Depression, prostration, ataxia, tremors and convulsions preceded death. There were no consistent biologically significant compound related effects in rats that received 60, 190 or 600 mg potassium picloram/kg/day for 14 days. In the subchronic study, rats received 60, 190, 600 or 1070 mg potassium picloram/kg/day for 90 consecutive days. There were only 4 male and 2 female survivors out of 20 rats of each sex at the 1070 mg/kg dose and 16 male and 18 female survivors at the 570 mg/kg dose. Mortality was dose-dependent. No specific organ site toxicity could be identified in these studies. Toxicity from exposure to picloram in drinking water is apparently low. (Copyright (c) 1986 by the Society of Toxicology.)
||Pub. in Fundamental and Applied Toxicology, v7 n3 p464-470 Oct 86. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
|NTIS Title Notes
||Reprint: Acute, 14-Day Repeated Dosing, and 90-Day Subchronic Toxicity Studies of Potassium Picloram (Journal Version).
||57Y; 57U; 44G; 68E; 68G
||PC A02/MF A01