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RECORD NUMBER: 15 OF 2643

OLS Field Name OLS Field Data
Main Title 7,12-Dimethylbenz(a)anthracene-Induced Modulation of Cytokines Involved in Cytotoxic T Lymphocyte Induction.
Author House, R. V. ; Pallardy, M. J. ; Burleson, G. R. ; Dean, J. H. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Chemical Industry Inst. of Toxicology, Research Triangle Park, NC. ;Sterling Research Group, Rensselaer, NY. Dept. of Toxicology.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/482;
Stock Number PB90-185273
Additional Subjects Lymphocytes ; Cytology ; Antigen antibody reactions ; Reprints ; Dimethylbenz(a)anthracene ; Cytokines ; Cytotoxic T lymphocytes ; Interferon type I ; Dose-response relationships ; Interferon type II ; Macrophage activation
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NTIS  PB90-185273 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/15/1990
Collation 14p
Abstract Murine lymphocytes were exposed to the carcinogenic polycyclic aromatic hydrocarbon 7,12-dimethylbenz(a)anthracene (DMBA) and several cytokines were measured. Production of interleukin-1 by macrophages, interleukin-2 by EL-4 thymoma, and gamma interferon by activated splenic lymphocytes were not affected by DMBA. However, interleukin-5 (also known as T cell replacing factor) was significantly suppressed by DMBA. Cloned cytotoxic T lymphocyte activity was inhibited in a dose-dependent manner by DMBA and the suppression was significantly enhanced by addition of beta or gamma interferon. The results support the hypothesis that, rather than acting as a non-specific inhibitor of lymphocyte proliferation, DMBA-induced suppression of antigen-specific cytolysis is a mechanism directed against highly-specific cellular targets in the immune process.
Supplementary Notes Pub. in In vitro Toxicology, a Jnl. of Molecular and Cellular Toxicology, v2 n4 p267-278 Dec 88. Prepared in cooperation with Chemical Industry Inst. of Toxicology, Research Triangle Park, NC., and Sterling Research Group, Rensselaer, NY. Dept. of Toxicology.
NTIS Title Notes Journal article.
Title Annotations Reprint: 7,12-Dimethylbenz(a)anthracene-Induced Modulation of Cytokines Involved in Cytotoxic T Lymphocyte Induction.
Category Codes 57Y; 57F
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 013024602
Origin NTIS
Type CAT