Main Title |
Estimating human equivalent no obeserved adverse effect levels for VOC's based on minimal knowledge of physiologic parameters / |
Author |
Overton, J. H. ;
Jarabek, A. M.
|
Other Authors |
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. |
Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory, |
Year Published |
1989 |
Report Number |
EPA600/D-89/097 |
Stock Number |
PB89-224588 |
Additional Subjects |
Formulas(Mathematics) ;
Toxicity ;
Blood chemical analysis ;
Estimating ;
Dosimetry ;
Mathematical models ;
Air pollution effects(Humans) ;
Pharmacokinetics ;
Dose-response relationships ;
Volatile organic compounds ;
No observed adverse effect level
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB89-224588 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
15 pages ; 28 cm |
Abstract |
The U.S. EPA advocates the assessment of health effects data and calculation of 'inhaled reference doses' as benchmark values for gauging systemic toxicity to inhaled gases. The assessment often requires an inter- or intra-species dose extrapolation from 'no observed adverse effect level' (NOAEL) exposure concentrations in animals to human equivalent NOAEL exposure concentrations. To achieve this, a dosimetric extrapolation procedure has been developed based on the form or type of equations that describe the uptake and disposition of inhaled volatile organic compounds (VOCs) in physiologically-based pharmacokinetic (PB-PK) models. The procedure assumes allometric scaling of most physiological parameters and that the value of the time integrated human arterial blood concentration must be limited to no more than to that of experimental animals. The scaling assumption replaces the need for most parameter values and allows the derivation of a simple formula for dose extrapolation of VOCs that gives equivalent or more conservative exposure concentrations values than those that would be obtained using a PB-PK model in which scaling was assumed. |
Notes |
"Technical paper submitted for 82nd Annual APCA Meeting, June 25-30, 1989, Anaheim, CA." Microfiche. |
Place Published |
Research Triangle Park, NC : |
Supplementary Notes |
Presented at the Annual APCA (Air Pollution Control Association) Meeting, Anaheim, CA., June 25-30, 1989. |
Corporate Au Added Ent |
United States. Environmental Protection Agency. ; Health Effects Research Laboratory. Environmental Toxicology Division. |
PUB Date Free Form |
1989. |
NTIS Prices |
PC A03/MF A01 |
BIB Level |
m |
Cataloging Source |
OCLC/T |
OCLC Time Stamp |
20000920170518 |
Language |
eng |
Origin |
NTIS |
Type |
MERGE |
OCLC Rec Leader |
01189nam 2200253Ka 45020 |