Main Title |
Bitertanol, a Triazole Fungicide, Increases Operant Responding but Not Motor Activity. |
Author |
Allen, A. R. ;
MacPhail, R. C. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;North Carolina Univ. at Chapel Hill. Dept. of Psychology. |
Publisher |
1993 |
Year Published |
1993 |
Report Number |
EPA/600/J-93/400; |
Stock Number |
PB93-236370 |
Additional Subjects |
Fungicides ;
Motor activity ;
Operant conditioning ;
Rats ;
Graphs(Charts) ;
Dose-response relationships ;
Reprints ;
Bitertanol ;
Triadimefon
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB93-236370 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
8p |
Abstract |
Several recent reports indicate that triadimefon, a triazole fungicide, has effects on behavior that are similar to those of psychomotor stimulants. For example, triadimefon increases overall fixed-interval (FI) response rate, disrupts FI response patterning, increases motor activity, and produces stereotypies at high doses. The study was designed to determine whether similar behavioral effects on FI performance and motor activity could be produced by another triazole fungicide, bitertanol. The effects of bitertanol (10-300 mg/kg, IP) were determined in rats on performance maintained under a multiple FI 1-min FI 5-min schedule of reinforcement. Intermediate doses of bitertanol increased response rates and disrupted response patterning in both FI components. A second experiment determined the effects of the same doses of bitertanol on motor activity. In contrast to its effects on operant responding, bitertanol did not increase motor activity at any of the doses tested. These findings indicate that the behavioral similarities between bitertanol and triadimefon are limited and that a dissociation exists between bitertanol's effects on operant performance and motor activity. (Copyright (c) 1993 Pergamon Press Ltd.) |
Supplementary Notes |
Pub. in Neurotoxicology and Teratology, v15 n4 p237-242 Jul 93. See also PB90-146234. Prepared in cooperation with North Carolina Univ. at Chapel Hill. Dept. of Psychology. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Bitertanol, a Triazole Fungicide, Increases Operant Responding but Not Motor Activity. |
Category Codes |
57Y; 68E |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
330925762 |
Origin |
NTIS |
Type |
CAT |