Main Title |
Direct Mutagen Risk Assessment: The Development of Methods to Measure Immunologic and Genetic Responses to Mutagens. |
Author |
Strauss, G. H. S. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1985 |
Report Number |
EPA/600/D-85/009; |
Stock Number |
PB85-160455 |
Additional Subjects |
Toxicology ;
Risk assessments ;
Responses ;
Mutagenesis ;
Immune response ;
Genetic response
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB85-160455 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
39p |
Abstract |
The review puts forward the concept of Direct Mutagen Risk Assessment through a discussion of the development of methods with which to measure immunologic and genetic responses to mutagens. Mutagenicity risk assessment, in this context, is the study of human somatic cell mutation occurring in vivo and is considered with attention to ideal criteria for detection of mutant cells. Immunotoxicity is addressed particularly in terms of the possible carcinogenic consequences of impaired cutaneous cell-mediated immunity. A section of this review reports the development and the exploitation of the Strauss-Albertini test for enumerating 6-thioquanine-resistant peripheral blood lymphocyte variants. Another section presents results from a system under development, designed to clone and quantitate mutant lymphocytes taken directly from the body. The Clonal Assay of Lymphocyte Mutagenesis (CALM) can confirm that variant cells are mutant and, potentially, could be used comparatively to measure genotoxicity in human or animal lymphocytes after in vivo or in vitro exposures to mutagens. |
PUB Date Free Form |
Jan 85 |
Category Codes |
6T; 6E; 57Y; 57J |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
511621782 |
Origin |
NTIS |
Type |
CAT |