Main Title |
Evidence for Monoaminergic Involvement in Triadimefon-Induced Hyperactivity. |
Author |
Crofton, K. M. ;
Boncek, V. M. ;
Macphail, R. C. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC. |
Publisher |
c1989 |
Year Published |
1989 |
Report Number |
EPA/600/J-89/396; |
Stock Number |
PB90-245986 |
Additional Subjects |
Toxicology ;
Fungicides ;
Laboratory animals ;
Enzyme inhibitors ;
Reserpine ;
Central nervous system ;
Reprints ;
Monoamines ;
Triadimefon ;
Hyperactivity ;
Motor activity ;
Dose-response relationships ;
Tyrosine hydroxylase ;
Drug antagonism
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-245986 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
6p |
Abstract |
Triadimefon is a triazole fungicide that produces hyperactivity in both mice and rats similar to that seen following administration of compounds with catecholaminergic activity (e.g., d-amphetamine). To determine whether the triadimefon-induced hyperactivity is due to an action on CNS catecholaminergic systems, the effects of combined treatment of triadimefon with either the tyrosine hydroxlase inhibitor d,l-alpha-methyl-p-tyrosine methyl ester HCl (alphaMPT) or the amine depletor reserpine were evaluated. Adult male Long-Evans hooded rats, approximately 70 days of age were used. Dosage-effect functions were determined for alphaMPT (0-200 mg/kg IP), reserpine (0-2.5 mg/kg IP), d-amphetamine (0-3 mg/kg IP), and methylphenidate (0-40 mg/kg IP). Motor activity was measured as photocell interruptions in figure-eight mazes. The interaction between triadimefon and alphaMPT was determined with the following groups: (1) vehicle control; (2) 200 mg/kg triadimefon PO; (3) 100 mg/kg alphaMPT; and (40 both alphaMPT and triadimefon. A similar design was used to determine the interaction between triadimefon and reserpine (0.62 mg/kg) alphaMPT and d-amphetamine (1.5 mg/kg), and reserpine and methylphenidate (5.0 mg/kg). (Copyright (c) Springer-Verlag 1989.) |
Supplementary Notes |
Pub. in Psychopharmacology, v97 p326-330 1989. Prepared in cooperation with Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Evidence for Monoaminergic Involvement in Triadimefon-Induced Hyperactivity. |
Category Codes |
57Y; 57S |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
024228523 |
Origin |
NTIS |
Type |
CAT |