Main Title |
Effects of Triadimefon on a Multiple Schedule of Fixed-Interval Performance: Comparison with Methylphenidate, d-Amphetamine and Chlorpromazine. |
Author |
Allen, A. R. ;
MacPhail., R. C. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;North Carolina Univ. at Chapel Hill. |
Publisher |
c1991 |
Year Published |
1991 |
Report Number |
EPA/600/J-92/021; |
Stock Number |
PB92-143932 |
Additional Subjects |
Fungicides ;
Toxicity ;
Psychomotor performance ;
Methylphenidate ;
Amphetamines ;
Chlorpromazine ;
Comparison ;
Rats ;
Motor activity ;
Dose-response relationships ;
Reprints ;
Triadimefon
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB92-143932 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
8p |
Abstract |
The experiment was designed to compare triadimefon to known psychomotor stimulants. Four rats were trained to perform under a mult FI 1-min FI 5-min schedule of milk reinforcement. They then received a series of dosages of triadimefon (10-170 mg/kg, i.p.) and of methylphenidate (1-17.3 mg/kg, i.p.) in a counterbalanced order. Certain dosages of triadimefon increased response rates for all rats in the FI 1-min component and in the FI 5-min component. Methylphenidate increased response rates in each component for only two rats. Temporal patterns of responding were disrupted more in the FI 5-min component than in the FI 1-min component by both triadimefon and methylphenidate. Performances were then evaluated following a series of dosages of d-amphetamine (0.3-3.0 mg/kg, i.p.) and chlorpromazine (0.5-2.0 mg/kg, i.p.). Response rates in FI 1-min were increased by d-amphetamine for three rats and in FI 5-min for two rats. d-Amphetamine, like triadimefon and methylphenidate, produced a greater disruption of response patterning in FI 5-min than in FI 1-min. Chlorpromazine only decreased response rates, but also produced some disruption in FI 5-min response patterning. |
Supplementary Notes |
Pub. in Pharmacology Biochemistry and Behavior, v40 n4 p775-780 Dec 91. See also PB89-109888. Prepared in cooperation with North Carolina Univ. at Chapel Hill. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Effects of Triadimefon on a Multiple Schedule of Fixed-Interval Performance: Comparison with Methylphenidate, d-Amphetamine and Chlorpromazine. |
Category Codes |
57Y; 57S; 68E |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
209921646 |
Origin |
NTIS |
Type |
CAT |