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RECORD NUMBER: 592 OF 1114

OLS Field Name OLS Field Data
Main Title Interactions of various pollutants on causation of pulmonary disease /
Author Ehrlich, Richard.
CORP Author IIT Research Inst., Chicago, IL.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher U.S. Environmental Protection Agency,
Year Published 1978
Report Number EPA-600/1-78-057; EPA-68-02-2274
Stock Number PB-288 363
OCLC Number 08962381
Subjects Respiratory organs--Diseases. ; Air--Pollution--Physiological effect.
Additional Subjects Respiratory diseases ; Toxicology ; Streptococcus ; Air pollution ; Interactions ; Exposure ; Infectious diseases ; Resistance ; Public health ; Mice ; Bacteria ; Pneumonia ; Enzymes ; Concentration(Composition) ; Nitrogen dioxide ; Ozone ; Tolerances(Physiology) ; Sulfur dioxide ; Ammonium sulfate ; Zinc sulfates ; Recommendations ; Experimental data ; Laboratory animals ; Toxic substances ; Infections ; Air pollution effects(Humans) ; Synergism ; Animal models ; Streptococcus pyogenes ; Environmental health
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
EJAD  EPA 600/1-78-057 Region 3 Library/Philadelphia, PA 01/14/2000
NTIS  PB-288 363 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation x, 48 pages
Abstract Studies were conducted to determine the effects of single and multiple exposures to individual and pollutant mixtures on resistance to respiratory infections. Results of NO2 studies indicate the greater importance of short-term peak concentrations than prolonged exposures to lower concentrations in increasing the susceptibility to infections. Single 3-hr exposure to mixtures containing various concentrations of NO2 and O3 had an additive effect. Repeated 3-hr exposures for 4 weeks to mixtures consisting of 3760 micrograms/cu m NO2 and 98 micrograms/cu m O3 suggested a synergistic interaction between the two pollutants. Daily 3-hr exposures for 6 months to mixtures of 940 micrograms/cu m NO2 and 196 micrograms/cu m O3 resulted in significant excess mortality, and reduced mean survival time in infected animals. Continuation of exposure to the pollutants for 14 days after the infectious challenge resulted in a pronounced increased susceptibility to the respiratory infection, after 1, 2 or 3 month exposure. In non-infected mice this exposure regimen induced changes in the activity of several serum enzymes.
Notes "PB-288 363." Report no. EPA-600/1-78-057. Prepared for Health Effects Research Laboratory, Research Triangle Park, N.C. Performing organization* IIT Research Institute, Chicago, Ill. Includes bibliographical references (pages 47-48). Mirofiche.
Place Published Research Triangle Park, N.C.,
Corporate Au Added Ent IIT Research Institute. ; Health Effects Research Laboratory (Research Triangle Park, N.C.)
PUB Date Free Form 1978.
NTIS Prices PC A04/MF A01
BIB Level m
Medium microform
Cataloging Source OCLC/T
OCLC Time Stamp 20031208134555
Language eng
Origin OCLC
Type MERGE
OCLC Rec Leader 01335cam 2200337Ia 45020