Main Title |
Effects of Intratracheally Administered Coarse Mode Particles on Respiratory Tract Infection in Mice. |
Author |
Aranyi, C. ;
Graf, J. L. ;
O'Shea, W. J. ;
Graham, J. A. ;
Miller, F. J. ;
|
CORP Author |
IIT Research Inst., Chicago, IL. Life Sciences Research Div.;Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1983 |
Report Number |
EPA/600/J-83/282; |
Stock Number |
PB85-176949 |
Additional Subjects |
Respiratory diseases ;
Mice ;
Laboratory animals ;
Quartz ;
Sodium feldspar ;
Ferric oxide ;
Calcium carbonate ;
Reprints ;
Particulates
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB85-176949 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
12p |
Abstract |
Because coarse mode particles are rarely studied in their existing size ranges (greatest mass about 5-7 micrometers, aerodynamic diameter), the authors investigated the effects of four such particles, quartz, ferric oxide, calcium carbonate, and sodium feldspar, on host defenses against bacterial pulmonary infection. Mice which received intratracheal instillations of 10, 33, and 100 microgram/mouse were exposed within an hour to aerosols of viable Streptococcus, and pneumonia-induced mortality was measured. At 33 and 100 microgram/mouse, all particles significantly increased mortality. At the lower dose, only Fe2O3 caused a significant increase in mortality. To evaluate potential delayed effects, mice were challenged with the bacteria 24 h after exposure to 100 microgram particles/mouse. Delaying the challenge did not significantly alter the response, except for the sodium feldspar group for which a partial recovery was observed. When mice exposed to 100 microgram particles/mouse received aerosols of Klebsiella pneumoniae 24 h later, there was no significant effect on pulmonary bactericidal activity. For the model system used, it appears that Fe2O3, CaCO3, and sodium feldspar have effects roughly equivalent to quartz. (Copyright (c) Elsevier Science Publishers B.V., 1983.) |
Availability Notes |
Pub. in Toxicology Letters 19, n1 p63-72 1983. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Effects of Intratracheally Administered Coarse Mode Particles on Respiratory Tract Infection in Mice. |
PUB Date Free Form |
c1983 |
Category Codes |
6T; 57Y; 68A |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
515818134 |
Origin |
NTIS |
Type |
CAT |