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OLS Field Name OLS Field Data
Main Title The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes Neuropsychological Endophenotypes and Biomarkers / [electronic resource] :
Type EBOOK
Author Ritsner, Michael S.
Publisher Springer Netherlands,
Year Published 2009
Call Number RC321-580
ISBN 9781402094644
Subjects Medicine. ; Human genetics. ; Neurosciences. ; Neurology. ; Psychiatry.
Internet Access
Description Access URL
http://dx.doi.org/10.1007/978-1-4020-9464-4
Collation XIV, 273 p. online resource.
Notes Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes Methodological and Technological Advances -- Where Do We Stand in the Quest for Neuropsychiatric Biomarkers and Endophenotypes and What Next? -- Methodological and Statistical Issues in the Use of Biomarkers in Clinical and Research Studies -- Challenging the Genetic Complexity of Schizophrenia by Use of Intermediate Phenotypes -- Translational Medicine: Functional Biomarkers for Drug Development of "Cognitive Enhancers" in Schizophrenia -- Leveraging High-Dimensional Neuroimaging Data in Genetic Studies of Neuropsychiatric Disease -- Proteomics as a New Tool for Biomarker-Discovery in Neuropsychiatric Disorders -- Schizophrenia Endophenotypes as Treatment Targets -- Neuropsychological, Neurocognitive and Neurophysiological Domains -- Neuropsychological Endophenotypes in Schizophrenia and Bipolar I Disorder: Yields from the Finnish Family and Twin Studies -- Is More Cognitive Experimental Psychopathology of Schizophrenia Really Necessary? Challenges and Opportunities -- Intellectual Functioning as an Endophenotype for Schizophrenia -- Emotion Recognition Deficits as a Neurocognitive Marker of Schizophrenia Liability -- The Use of Neurocognitive Endophenotypes in Large-Scale Family Genetic Studies of Schizophrenia -- Neurocognitive Endophenotypes for Bipolar Disorder: Evidence from Case-Control, Family and Twin Studies -- Trait and State Markers of Schizophrenia in Visual Processing -- Visual Scanning Abnormalities as Biomarker for Schizophrenia -- Biomarkers and Endophenotypes in Eating Disorders -- Movement Abnormalities: A Putative Biomarker of Risk for Psychosis. Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer's disease, epilepsy, alcoholism, substance abuse and others are some of the most debilitating illnesses worldwide characterizing by the complexity of the causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunity to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances into meaningful diagnostic and therapeutic advances. This book offers a broad synthesis of the current knowledge about diverse topics of the biomarker and endophenotype strategies in neuropsychiatry. The book is organized into four interconnected volumes: "Neuropsychological Endophenotypes and Biomarkers" (with overview of methodological issues of the biomarker and endophenotype approaches in neuropsychiatry and some technological advances), "Neuroanatomical and Neuroimaging Endophenotypes and Biomarkers", "Metabolic and Peripheral Biomarkers" and "Molecular Genetic and Genomic Markers". The contributors are internationally and nationally recognized researchers and experts from 16 countries. This four-volume handbook is intended for a broad spectrum of readers including neuroscientists, psychiatrists, neurologists, endocrinologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, health care providers in the field of neurology and mental health interested in trends that have crystallized in the last decade, and trends that can be expected to further evolve in the coming years. It is hoped that this book will also be a useful resource for the teaching of psychiatry, neurology, psychology and mental health.
Place Published Dordrecht
Corporate Au Added Ent SpringerLink (Online service)
Host Item Entry Springer eBooks
PUB Date Free Form 2009
BIB Level m
Medium computer
Content text
Carrier online resource
Cataloging Source OCLC/T
OCLC Time Stamp 20140915023621
Language eng
Origin SPRINGER
Type EBOOK
OCLC Rec Leader 05106nam a22004815i 45