Main Title |
Influence of Cortisol on Prostaglandin Synthesis by Fetal Membranes, Placenta, and Uterus of Pregnant Rabbits (Journal Version). |
Author |
Fail, P. A. ;
Reynolds, R. P. ;
|
CORP Author |
North Carolina State Univ. at Raleigh. ;Research Triangle Inst., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1987 |
Year Published |
1987 |
Report Number |
EPA/600/J-87/383; |
Stock Number |
PB89-106827 |
Additional Subjects |
Fetal membranes ;
Hydrocortisone ;
Prostaglandins ;
Prostaglandin synthase ;
Uterus ;
Placenta ;
Laboratory animals ;
Microsomes ;
Induced abortion ;
Amniotic fluid ;
Pregnancy ;
Progesterone ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB89-106827 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
Two experiments were designed to assess the effects of cortisol on prostaglandin-forming cyclooxygenase in 4 gestational tissues of rabbits. Cortisol treatment (12 mg/kg body wt/h) was initiated on day 21 of pregnancy and continued for a 24-h period. In cortisol-treated rabbits, plasma progesterone decreased (P<.01) from 7.2 + or - 0.8 ng/ml on day 21 (pretreatment) to 1.6 + or - 0.2 ng/ml on day 23, 48 hrs after the initiation of cortisol treatment. By 62 h, PGF, PGE2, and cortisol concentrations were all significantly higher (P<.05) in the amniotic fluid of treated animals. However, cortisol treatment did not increase prostaglandin-forming cyclooxygenase activity in fetal or maternal tissues at either 48 or 62 h. Therefore, even though increased prostaglandin production may be responsible for the cortisol-induced abortion, increased cyclooxygenase activity in the gestational compartment was not detected. |
Supplementary Notes |
Pub. in Biology of Reproduction, v37 p47-54 1987. Prepared in cooperation with Research Triangle Inst., Research Triangle Park, NC. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Influence of Cortisol on Prostaglandin Synthesis by Fetal Membranes, Placenta, and Uterus of Pregnant Rabbits (Journal Version). |
Category Codes |
57S; 57Q |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
834422636 |
Origin |
NTIS |
Type |
CAT |