Main Title |
Use of Bromoergocryptine in the Validation of Protocols for the Assessment of Mechanisms of Early Pregnancy Loss in the Rat. |
Author |
Cummings, A. M. ;
Perreault, S. D. ;
Harris, S. T. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;NSI Technology Services Corp., Research Triangle Park, NC. |
Publisher |
c1991 |
Year Published |
1991 |
Report Number |
EPA/600/J-91/313; |
Stock Number |
PB92-124692 |
Additional Subjects |
Animal pregnancy ;
Missed abortion ;
Bromocriptine ;
Corpus luteum ;
Pituitary gland ;
Embryo ;
Rats ;
Ovariectomy ;
Progesterone ;
Risk assessment ;
Organ weight ;
Reprints ;
Early Pregnancy Protocol
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB92-124692 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
14p |
Abstract |
Validated protocols for evaluating maternally mediated mechanisms of early pregnancy failure in rodents are needed for use in the risk assessment process. To supplement previous efforts in the validation of a panel of protocols assembled for the purpose, bromoergocryptine (BEC) was used as a model compound because it is known to inhibit pituitary prolactin secretion. BEC was tested using the early pregnancy protocol (EPP), the decidual cell response technique (DCR), the pre- vs postimplantation protocol (PPP), and embryo transport rate analysis (ETRA). These protocols evaluate the effects of chemicals on multiple endpoints following exposure during (1) the first 8 days of pregnancy, (2) early pseudopregnancy accompanied by decidual induction, (3) the pre- and postimplantation intervals of early pregnancy, or (4) the period of embryo transport. In the EPP, dosing with BEC during Days 1-8 of pregnancy reduced the number of implantation sites found on Day 9 as well as serum progesterone. The DCR technique revealed a dose-dependent inhibition of decidual growth concomitant with decreased serum progesterone as a result of BEC treatment. A modified DCR technique using hormone-supplemented ovariectomized rats demonstrated that BEC did not impair decidual growth in the presence of adequate progestogenic support. (Copyright (c) 1991 by the Society of Toxicology.) |
Supplementary Notes |
Pub. in Fundamental and Applied Toxicology, v17 n3 p563-574 Oct 91. See also PB90-217449. Prepared in cooperation with NSI Technology Services Corp., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Use of Bromoergocryptine in the Validation of Protocols for the Assessment of Mechanisms of Early Pregnancy Loss in the Rat. |
Category Codes |
57S |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
202429041 |
Origin |
NTIS |
Type |
CAT |