Main Title |
Determination of Minimal Infectious Dose of an Enterovirus in Drinking Water. |
Author |
Schiff, Gilbert M. ;
Stefanovic', Gerda ;
Young, Elizabeth ;
Pennekamp, Julia ;
|
CORP Author |
Christ Hospital, Cincinnati, OH. Inst. of Medical Research.;Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1983 |
Report Number |
EPA-R-806173; EPA-600/1-83-004; |
Stock Number |
PB83-191015 |
Additional Subjects |
Enteroviruses ;
Viruses ;
Potable water ;
Dosage ;
Ingestion(Biology) ;
Males ;
Drinking water
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB83-191015 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
38p |
Abstract |
The goals of this project were to determine the minimal infectious dose and medical significance of an enteric virus ingested in drinking water. The study was conducted under double-blind, placebo-controlled, random-selection conditions. A total of 149 susceptible (antibody-free), healthy, young adult males ingested varying doses of ECHO-12 virus (10-10,000 pfu) or placebo seeded into 100 ml of non-chlorinated water and were followed for evidence of illness, viral shedding, and antibody response. There was no illness in any of the subjects and no evidence for infection among the placebo subjects. Infection in exposed subjects was primarily demonstrated by fecal shedding of virus. |
NTIS Title Notes |
Final rept. 25 Jan 79-30 Sep 81. |
PUB Date Free Form |
Apr 83 |
Category Codes |
6F; 6M; 68D; 57K |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
320324608 |
Origin |
NTIS |
Type |
CAT |