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RECORD NUMBER: 492 OF 2075

OLS Field Name OLS Field Data
Main Title Draft Criteria Document for 1,2, Dichloropropane.
CORP Author Environmental Protection Agency, Washington, DC. Science Advisory Board.
Publisher 9 Mar 88
Year Published 1988
Report Number SAB/EHC-88/018;
Stock Number PB89-114508
Additional Subjects Chlorine aliphatic compounds ; Water pollution abatement ; Potable water ; Carcinogens ; Public health ; Laboratory animals ; Risk assessment ; Safe Drinking Water Act
Internet Access
Description Access URL
https://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=P100JVQV.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB89-114508 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/14/1989
Collation 5p
Abstract The Halogenated Organics Subcommittee of the EPA Science Advisory Board's Environmental Health Committee conducted an independent scientific review of the Office of Drinking Water's Draft Criteria Document for 1,2 Dichloropropane. The Subcommittee unanimously concluded that the drinking water equivalent level should not be based on the non-carcinogenic endpoints of the National Toxicology Program's 1986 bioassay in male rats. It offered five reasons for this conclusion: (1) the dose of 62 mg/kg bw/day represents a no-observed-effect-level for cancer in male rats; (2) the endpoints of survival, body weight organs and tissues are not sufficiently sensitive; (3) histological lesions were observed in the testes of some male rats given the 62 mg dose; (4) evidence indicated that the chemical may be a male reproductive toxic; and (5) the NTP bioassay was not designed to supply data for derivation of a drinking water equivalent level.
NTIS Title Notes Final rept.
Category Codes 57U; 57H; 57Y; 68D; 68G
NTIS Prices PC A02/MF A01
Primary Description 100/00
Document Type NT
Cataloging Source NTIS/MT
Control Number 836524013
Origin NTIS
Type CAT