||Toxicity equivalency factors for PCBs
Barnes, D. ;
Alford-Stevens, A. ;
Birnbaum, L. ;
Kutz, F. W. ;
||Health Effects Research Lab., Research Triangle Park, NC.
||Health Effects Research Laboratory, U.S Environmental Protection Agency ;
||PB92-113349 ; EPA/600/J-91/272
Polychlorinated biphenyls--Environmental aspects ;
Polychlorinated biphenyls--Toxicology ;
Polychlorobiphenyl compounds ;
Health hazards ;
Risk assessment ;
Toxicity equivalency factors ;
Chlorinated dibenzo-p-dioxins ;
||Region 10 Library/Seattle,WA
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||12 p. : ill.
||In December 1990 the U.S. Environmental Protection Agency sponsored a workshop to discuss the applicability of an interim 'toxicity equivalency factor' (TEF) approach to assessing risks posed by exposures to complex mixtures of polychlorinated biphenyls (PCBs). The group concluded that application of the TEF approach to PCBs would be less straightforward than it was in the case of chlorinated dibenzo-p-dioxins and dibenzofurans (CDDs/CDFs). It appears that 'dioxin'-like properties of some PCB congeners are amenable to a TEF treatment that is compatible with that used for CDDs/CDFs. Such a scheme also seems to have utility in assessing risks to wildlife. Other non-'dioxin'-like toxic endpoints (e.g., neurotoxicity) appear to have a different structure-activity-related mechanism-of-action that requires a separate TEF scheme. The workshop identified data gaps in toxicology and analytical chemistry that hinder adoption of proposed TEF schemes for PCBs at this time. (Copyright (c) 1991 by Academic Press, Inc.)
||"EPA/600/J-91/272." "PB92-113349." Contains bibliographic references at end of paper.
||Research Triangle Park, N.C. :
||Pub. in Quality Assurance: Good Practice, Regulation, and Law, v1 n1 p70-81 Oct 91.
|Corporate Au Added Ent
||Health Effects Research Laboratory (Research Triangle Park, N.C.)
|PUB Date Free Form
||PC A03/MF A01
|OCLC Time Stamp
|OCLC Rec Leader
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