||Female Reproductive and Developmental Toxicology: Overview and Current Approaches.
Kamrin, M. A. ;
Carney, E. W. ;
Chou, K. ;
Cummings, A. ;
Dostal, L. A. ;
||Michigan State Univ., East Lansing. Dept. of Animal Science. ;Michigan Univ., Ann Arbor. School of Public Health. ;Dow Chemical Co., Midland, MI. Toxicology Research Lab. ;Rochester Univ., NY. Dept. of Obstetrics and Gynecology.;Environmental Protection Agency, Research Triangle Park, NC. Reproductive Toxicology Branch.
Environmental pollutants ;
Maternal-fetal exchange ;
Cell differentiation ;
Methylmercury compounds ;
Gap junctions ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||In recent years, concern about possible female reproductive and developmental toxicity due to environmental contaminants, such as PCBs, has been growing. Because this area of toxicology had not been emphasized prior to this time, there are many gaps in current knowledge about female developmental and reproductive toxicology and only a limited number of validated tests to assay effects of toxicants on various parts of the reproductive and developmental cycle. This article reviews the current state of knowledge on this topic and also explores a variety of techniques for assessing female reproductive and developmental toxicity. These include an assay of the state of intercellular communication among the embryo, fetus and placenta; protocols for assessing toxicity in early pregnancy; and techniques for evaluating the role of glutathione in protecting the conceptus from xenobiotics.
||Pub. in Toxicology Letters 74, n2 p99-119 Nov 94. Prepared in cooperation with Michigan Univ., Ann Arbor. School of Public Health., Dow Chemical Co., Midland, MI. Toxicology Research Lab., and Rochester Univ., NY. Dept. of Obstetrics and Gynecology. Sponsored by Environmental Protection Agency, Research Triangle Park, NC. Reproductive Toxicology Branch.
||%AUT:C. /Harris ;J. W. /Henck ;R. /Loch-Caruso ;R. K. /Miller
|NTIS Title Notes
||Reprint: Female Reproductive and Developmental Toxicology: Overview and Current Approaches.
||57Y; 57S; 68G
||PC A03/MF A01