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RECORD NUMBER: 626 OF 2887

OLS Field Name OLS Field Data
Main Title Controlled Clinical Evaluations of Chlorine Dioxide, Chlorite and Chlorate in Man.
Author Lubbers, Judith R. ; Chauan, Sudha ; Bianchine, Joseph R. ;
CORP Author Ohio State Univ., Columbus. Coll. of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1982
Report Number EPA-R-805643; EPA-600/J-81-367;
Stock Number PB83-187856
Additional Subjects Disinfectants ; Chlorine dioxide ; Chlorite ; Chlorate ; Toxicology ; Humans ; Safety ; Tolerance(Physiology) ; Physiological effects ; Reprints ; Water pollution effects(Humans)
Holdings
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Status
NTIS  PB83-187856 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 8p
Abstract To assess the relative safety of chronically administered chlorine water disinfectants in man, a controlled study was undertaken. The clinical evaluation was conducted in the three phases common to investigational drug studies. Phase I, a rising does tolerance investigation, examined the acute effects of progressively increasing single doses of chlorine disinfectants to normal healthy adult male volunteers. Phase II considered the impact on normal subjects of daily ingestion of the disinfectants at a concentration of 5mg/l. for twelve consecutive weeks. Persons with a low level of glucose-6-phosphate dehydrogenase may be expected to be especially susceptible to oxidative stress; therefore, in Phase III, chlorite at a concentration of 5mg/l. was administered daily for twelve consecutive weeks to a small group of potentially at-risk glucose-6-phosphate dehydrogenase-deficient subjects.
Supplementary Notes Pub. in Environmental Health Perspectives, v46 p57-62 1982.
NTIS Title Notes Journal article.
Title Annotations Reprint: Controlled Clinical Evaluations of Chlorine Dioxide, Chlorite and Chlorate in Man.
PUB Date Free Form 1982
Category Codes 6T; 6F; 57Y; 68D
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 320321834
Origin NTIS
Type CAT