Main Title |
Toxicity of 2-Nitropropane with Cover Letter dated 04/26/94. |
CORP Author |
Angus Chemical Co.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
1994 |
Report Number |
8EHQ-86940000359 |
Stock Number |
OTS0572462 |
Additional Subjects |
Toxicology ;
Health effects ;
2-Nitropropane ;
Toxicity ;
Acute toxicity ;
Mammals ;
Rabbits ;
Inhalation ;
Guinea pigs ;
Cats ;
Dogs ;
Subchronic toxicity ;
Monkeys ;
Pharmaco kinetics ;
CAS No 79-46-9 ;
Toxic substances ;
Laboratory animals ;
Rats
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0572462 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
130p |
Abstract |
Experimental work was undertaken to provide a basis for appraising the hazards which may attend the use of 2-nitropropane ((CH3)(2)C(H)NO) as a solvent. Skinner reported that workers complained of severe headache and gastroenteric disturbances while using 2-nitropropane on a damp day in a poorly ventilated shed. The results of analyses, performed presumably on another day, suggested that the atmospheric concentrations that gave rise to the complaints may have been of the order of 15 to 45 parts per million (ppm). The physical properties of this nitroparaffin and the toxicity shown by it when it was administered orally to rabbits have been reported previously. At a pressure of 745 mm. of mercury and a temperature of 25 C. (77 F) air saturated with volatilized 2-nitropropane would contain 95.8 mg. per liter since at this temperature the vapor pressure is 20 mm. Under similar conditions the concentration of 1 mg. of 2-nitropropane per liter of air is equivalent to 280.1 ppm. Its odor was detectable at 1.05 mg. per liter (294.0 ppm) but not at 0297 mg. per liter (83 ppm). The work described in this article was sponsored by the Commercial Solvents Corporation, whose financial aid is gratefully acknowledged, as is also their assist- ance in supplying the material for investigation. |
Supplementary Notes |
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Availability Notes |
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PUB Date Free Form |
Apr 1994 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A08/MF A08 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
010501530 |
Origin |
NTIS |
Type |
CAT |